Watanabe H
Nihon Geka Gakkai Zasshi. 1985 Dec;86(12):1654-63.
The euglobulin lysis time (ELT) in antecubital vein and femoral vein was investigated in 35 patients before and after bilateral intermittent sequential leg compression for one hour. After compression, ELT in antecubital vein was shortened, and that in femoral vein was significantly shortened (p less than 0.05). beta-thromboglobulin, fibrinopeptide B beta 15-42 and alpha 2-plasmin inhibitor were also investigated, but no significant change was found after compression. The mean and peak blood velocity of the femoral vein before and during compression was measured using Doppler ultrasound in 20 patients. The mean blood velocity increased about 183% (p less than 0.001), and the peak blood velocity also increased 178% (p less than 0.001). ELT was measured pre- and post-operatively in 31 patients who had intermittent sequential compression during operation and succeeding two days and in 31 controls which had no compression. Both in antecubiltal vein and in femoral vein, ELT in the compression group was significantly shorter than that of control group in the first postoperative day. This study demonstrates that intermittent sequential compression of the legs increased fibrinolytic activity, and this effect may contribute to the prevention of deep venous thrombosis.
对35例患者在双侧间歇性序贯腿部压迫1小时前后，检测其肘前静脉和股静脉的优球蛋白溶解时间（ELT）。压迫后，肘前静脉的ELT缩短，股静脉的ELT显著缩短（p<0.05）。还检测了β-血小板球蛋白、纤维蛋白肽Bβ15 - 42和α2 - 纤溶酶抑制剂，但压迫后未发现显著变化。使用多普勒超声对20例患者在压迫前和压迫过程中测量股静脉的平均血流速度和峰值血流速度。平均血流速度增加约183%（p<0.001），峰值血流速度也增加178%（p<0.001）。对31例在手术及术后连续两天进行间歇性序贯压迫的患者和31例未进行压迫的对照组患者在术前和术后检测ELT。在术后第一天，压迫组肘前静脉和股静脉的ELT均显著短于对照组。本研究表明，间歇性序贯腿部压迫可增加纤溶活性，且这种作用可能有助于预防深静脉血栓形成。
