Mahbuba Sharmin, Mohsin Fauzia, Rahat Farhana, Nahar Jebun, Begum Tahmina, Nahar Nazmun
BIRDEM General Hospital, Dhaka, Bangladesh.
Shishu Shashthyo Foundation Hospital and Institute of Child Health, Dhaka, Bangladesh.
Diabetes Metab Syndr. 2018 May;12(3):369-374. doi: 10.1016/j.dsx.2017.12.026. Epub 2018 Jan 4.
The study was done to assess the magnitude of problems of metabolic syndrome among obese adolescents.
It was a cross-sectional study done from January 2013 to June 2014 in paediatric endocrine outpatient department in BIRDEM General Hospital, Dhaka, Bangladesh. Total 172 adolescents having exogenous obesity aged 10-18 years were included. Impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and type 2 diabetes mellitus (DM) were defined as per WHO criteria.The adolescents having Body Mass Index (BMI) ≥95th centile were classified as obese.Waist circumference was measured at the level midway between the lower rib margin & the iliac crest, at the level of umbilicus with the person breathing out gently in centimeter. Hip circumference was measured at the maximum width over the buttocks at the level of the greater trochanters in centimeter.
Among 172 obese adolescents, metabolic syndrome was found in 66 patients (38.4%). The commonest metabolic abnormality among those having metabolic syndrome was low HDL level (77.3%) followed by high triglyceride level(71.2%). Glucose intolerance (IFG and/or IGT) was found in 16.7%, Type 2 DM in 10.6%, systolic hypertension in 10.7% and diastolic hypertension in 12.1%. Triglyceride (p = 0.042) and Cholesterol level (p = 0.016) were significantly higher and HDL-cholesterol level (p = 0.000) was significantly lower among obese adolescents having metabolic syndrome. Less physical activity (p = 0.04) was significantly related to the development of metabolic syndrome. On logistic regression analysis male sex, family history of obesity and low HDL-cholesterol correlated to metabolic syndrome.
The High rate of metabolic syndrome among obese adolescents is alarming.
本研究旨在评估肥胖青少年代谢综合征问题的严重程度。
这是一项于2013年1月至2014年6月在孟加拉国达卡BIRDEM综合医院儿科内分泌门诊进行的横断面研究。共纳入172名年龄在10 - 18岁的外源性肥胖青少年。空腹血糖受损（IFG）、糖耐量受损（IGT）和2型糖尿病（DM）根据世界卫生组织标准定义。体重指数（BMI）≥第95百分位数的青少年被归类为肥胖。腰围在呼气时于下肋骨边缘与髂嵴之间的中点水平、脐水平测量，单位为厘米。臀围在大转子水平臀部最宽处测量，单位为厘米。
在172名肥胖青少年中，66名患者（38.4%）患有代谢综合征。代谢综合征患者中最常见的代谢异常是高密度脂蛋白水平低（77.3%），其次是甘油三酯水平高（71.2%）。糖耐量异常（IFG和/或IGT）占16.7%，2型糖尿病占10.6%，收缩期高血压占10.7%，舒张期高血压占12.1%。患有代谢综合征的肥胖青少年甘油三酯（p = 0.042）和胆固醇水平（p = 0.016）显著更高，高密度脂蛋白胆固醇水平（p = 0.000）显著更低。运动量少（p = 0.04）与代谢综合征的发生显著相关。逻辑回归分析显示，男性、肥胖家族史和高密度脂蛋白胆固醇低与代谢综合征相关。
肥胖青少年中代谢综合征的高发生率令人担忧。
