Li Xun, Hou Yuying, Ren Yanping, Tian Xin, Song Yijun
Department of Neurology, Tianjin Medical University General Hospital, Key Laboratory of Neurotrauma, Variation and Regeneration, Ministry of Education and Tianjin Municipal Government, Tianjin Neurological Institute, Tianjin 300052, China.
School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, China.
Epilepsy Res. 2018 Feb;140:148-154. doi: 10.1016/j.eplepsyres.2017.12.017. Epub 2018 Jan 10.
Attention dysfunction, especially executive control has been investigated within many types of diseases of the central nervous system. The present study aims to clarify alterations of the executive control (EC) network in patients with temporal lobe epilepsy (TLE). Twenty patients with TLE and 20 matched healthy control subjects participated in the attention network test (ANT), and scalp electroencephalogram (EEG) recordings were set up. The ANT was used to evaluate attention network behavior deficits. Power spectral density (PSD), coherence and correlation were used to detect power and oscillation alterations of attention network in patients with TLE. The most significant differences in executive control were found between patients with TLE and healthy control subjects. Power spectral density in the theta band, and coherence and correlation in the theta band in the frontal area were decreased in patients with TLE. Our results indicate that patients with TLE have severe attention dysfunction, especially in executive control. In addition, brain theta oscillation impairment in frontal area might be connected with poor executive control behavior. These findings will provide new insight into diagnosing and treating patients with temporal lobe epilepsy.
注意力功能障碍，尤其是执行控制，已在多种中枢神经系统疾病中得到研究。本研究旨在阐明颞叶癫痫（TLE）患者执行控制（EC）网络的改变。20例TLE患者和20例匹配的健康对照者参与了注意力网络测试（ANT），并进行了头皮脑电图（EEG）记录。ANT用于评估注意力网络行为缺陷。功率谱密度（PSD）、相干性和相关性用于检测TLE患者注意力网络的功率和振荡改变。TLE患者与健康对照者之间在执行控制方面存在最显著差异。TLE患者额叶区域θ波段的功率谱密度以及θ波段的相干性和相关性均降低。我们的结果表明，TLE患者存在严重的注意力功能障碍，尤其是在执行控制方面。此外，额叶区域的脑θ振荡受损可能与执行控制行为不佳有关。这些发现将为颞叶癫痫患者的诊断和治疗提供新的见解。
