The CGD Center for Multiple Sclerosis, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Cold Spring Harb Perspect Med. 2018 Sep 4;8(9):a028928. doi: 10.1101/cshperspect.a028928.
The 1996 originally established multiple sclerosis (MS) subtypes, based solely on clinical impression and consensus, were revised in 2013 to review potential imaging and biological correlates and to reflect recently identified clinical aspects of MS. As a result, potential new disease phenotypes, radiologically isolated syndrome, and clinically isolated syndrome were considered along with the addition of two new descriptor subtypes: activity and progression applied to relapsing remitting and progressive MS phenotypes. In this way, the description of an individual patient's disease course is refined and provides temporal information about the ongoing disease process. There is still a lack of imaging and biological markers that would distinguish MS phenotypes and prognosticate the disease course on an individual patient's level, creating a pressing need for large collaborative research efforts in this field.
1996 年最初根据临床印象和共识确定的多发性硬化（MS）亚型，在 2013 年进行了修订，以回顾潜在的影像学和生物学相关性，并反映 MS 的最近确定的临床方面。因此，考虑了潜在的新疾病表型、孤立综合征和临床孤立综合征，同时还增加了两种新的描述符亚型：活动期和进展期，适用于复发缓解型和进行型 MS 表型。这样，就可以细化个体患者疾病过程的描述，并提供关于正在进行的疾病过程的时间信息。目前仍然缺乏可以区分 MS 表型并预测个体患者疾病进程的影像学和生物学标志物，这就迫切需要在该领域开展大型合作研究。
