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EZH2 mutations in chronic myelomonocytic leukemia cluster with ASXL1 mutations and their co-occurrence is prognostically detrimental.

作者信息

Patnaik Mrinal M, Vallapureddy Rangit, Lasho Terra L, Hoversten Katherine P, Finke Christy M, Ketterling Rhett, Hanson Curtis, Gangat Naseema, Tefferi Ayalew

机构信息

Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

出版信息

Blood Cancer J. 2018 Jan 22;8(1):12. doi: 10.1038/s41408-017-0045-4.

DOI:10.1038/s41408-017-0045-4
PMID:29358618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5802714/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/642c/5802714/f7dddfbf0309/41408_2017_45_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/642c/5802714/f7dddfbf0309/41408_2017_45_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/642c/5802714/f7dddfbf0309/41408_2017_45_Fig1_HTML.jpg

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Polycomb repressive complexes in hematological malignancies.多梳抑制复合物在血液系统恶性肿瘤中的作用。
Blood. 2017 Jul 6;130(1):23-29. doi: 10.1182/blood-2017-02-739490. Epub 2017 May 8.
2
DNMT3A mutations are associated with inferior overall and leukemia-free survival in chronic myelomonocytic leukemia.DNMT3A 突变与慢性粒单核细胞白血病的总生存和无白血病生存不良相关。
Am J Hematol. 2017 Jan;92(1):56-61. doi: 10.1002/ajh.24581. Epub 2016 Dec 7.
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Chronic myelomonocytic leukemia: 2016 update on diagnosis, risk stratification, and management.
克隆性造血的临床进展由突变时间、适应性和克隆结构共同决定。
bioRxiv. 2025 Mar 3:2025.02.28.640879. doi: 10.1101/2025.02.28.640879.
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Chronic myelomonocytic leukemia: 2024 update on diagnosis, risk stratification and management.慢性粒单核细胞白血病：2024 年诊断、风险分层和治疗更新。
Am J Hematol. 2024 Jun;99(6):1142-1165. doi: 10.1002/ajh.27271. Epub 2024 Mar 7.
5
Concurrent chronic myelomonocytic leukemia and gastric carcinoma: a case report and literature review.慢性粒单核细胞白血病与胃癌并存：一例报告及文献综述
AME Case Rep. 2023 Sep 7;7:37. doi: 10.21037/acr-23-12. eCollection 2023.
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Haploidentical donor hematopoietic cell transplantation for myelodysplastic/myeloproliferative overlap neoplasms: results from a North American collaboration.单倍体相合供者造血细胞移植治疗骨髓增生异常/骨髓增殖性肿瘤重叠综合征：来自北美合作的结果。
Haematologica. 2023 Dec 1;108(12):3321-3332. doi: 10.3324/haematol.2023.283426.
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Co-existing squamous cell carcinoma and chronic myelomonocytic leukemia with and gene mutations: A case report.并存鳞状细胞癌和伴有 和 基因突变的慢性粒单核细胞白血病：一例报告。
World J Clin Cases. 2023 May 26;11(15):3643-3650. doi: 10.12998/wjcc.v11.i15.3643.
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Res Sq. 2023 Mar 21:rs.3.rs-2691216. doi: 10.21203/rs.3.rs-2691216/v1.
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Blood. 2016 May 19;127(20):2391-405. doi: 10.1182/blood-2016-03-643544. Epub 2016 Apr 11.
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Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents.在对去甲基化药物有反应的慢性粒单核细胞白血病中，突变等位基因负担保持不变。
Nat Commun. 2016 Feb 24;7:10767. doi: 10.1038/ncomms10767.
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Leukemia. 2014 Nov;28(11):2206-12. doi: 10.1038/leu.2014.125. Epub 2014 Apr 3.
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J Clin Oncol. 2013 Jul 1;31(19):2428-36. doi: 10.1200/JCO.2012.47.3314. Epub 2013 May 20.
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Leukemia. 2011 Jul;25(7):1200-2. doi: 10.1038/leu.2011.58. Epub 2011 Apr 1.