El Hussein Siba, Wang Sa A, Pemmaraju Naveen, Khoury Joseph D, Loghavi Sanam
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
J Immunother Precis Oncol. 2021 Jun 18;4(3):142-149. doi: 10.36401/JIPO-21-1. eCollection 2021 Aug.
Our understanding of chronic myelomonocytic leukemia (CMML) has evolved tremendously over the past decade. Large-scale sequencing studies have led to increased insight into the genomic landscape of CMML and clinical implications of these changes. This in turn has resulted in refined and improved risk stratification models, which to date remain versatile and subject to remodeling, as new and evolving studies continue to refine our understanding of this disease. In this article, we present an up-to-date review of CMML from a hematopathology perspective, while providing a clinically practical summary that sheds light on the constant evolution of our understanding of this disease.
在过去十年中，我们对慢性粒单核细胞白血病（CMML）的认识有了巨大的发展。大规模测序研究使我们对CMML的基因组格局及其变化的临床意义有了更深入的了解。这反过来又带来了更精细和完善的风险分层模型，迄今为止，这些模型仍然通用且有待完善，因为新的不断发展的研究持续深化我们对这种疾病的认识。在本文中，我们从血液病理学角度对CMML进行了最新综述，同时提供了一份临床实用总结，以阐明我们对这种疾病认识的不断演变。
