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复方乌梅散通过Cox-2/PGE2-PI3K/AKT/GSK3/-连环蛋白信号通路抑制胃癌的侵袭和转移。

Compound Wumei Powder Inhibits the Invasion and Metastasis of Gastric Cancer via Cox-2/PGE2-PI3K/AKT/GSK3/-Catenin Signaling Pathway.

作者信息

Ma Nai-Xia, Sun Wei, Wu Jian, Liu Shen-Lin, Weng Lei, Liu Yang-Qing, Pu Wen-Xiu, Wu Ting-Ting, Ding Xue-Lian, Huang Nan-Guang, Zheng Pei-Qiu, Zou Xi

机构信息

The Affiliated Hospital of Nanjing University of TCM, Jiangsu Province Hospital of TCM, Nanjing 210029, China.

No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China.

出版信息

Evid Based Complement Alternat Med. 2017;2017:3039450. doi: 10.1155/2017/3039450. Epub 2017 Nov 21.

DOI:10.1155/2017/3039450
PMID:29358963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5735682/
Abstract

To explore the role of CWP in invasion and migration of gastric cancer cells and its underlying molecular mechanism, we performed the experiment in SGC-7901 cells both and . In the cell experiment, we evaluated cell proliferation by MTT assay. The results showed that CWP can inhibit the growth of SGC-7901 cells. The influence on cell migration and invasion was detected by wound-healing and Transwell invasion assays. The results showed that the abilities of invasion and migration are restrained in CWP group. Western blot showed that CWP can decrease the expression of Cox-2 and inhibit the PI3K/AKT/GSK3/-catenin signaling pathway. In the animal experiment, we observed that CWP had an inhibitory effect on the growth of xenograft tumors of nude mice. IHC assay, ELISA, RT-PCR assay, and Western blot assay were used to test relevant cytokines of Cox-2/PGE2-PI3K/AKT/GSK3/-catenin pathway. The results showed that CWP can suppress relevant cytokines of Cox-2/PGE2-PI3K/AKT/GSK3/-catenin pathway. In conclusion, we suggest that CWP inhibits the invasion and metastasis of SGC-7901 cells via Cox-2/PGE2-PI3K/AKT/GSK3/-catenin signaling pathway.

摘要

为了探究CWP在胃癌细胞侵袭和迁移中的作用及其潜在分子机制，我们在SGC - 7901细胞中进行了相关实验。在细胞实验中，我们通过MTT法评估细胞增殖。结果显示，CWP可抑制SGC - 7901细胞的生长。通过伤口愈合实验和Transwell侵袭实验检测对细胞迁移和侵袭的影响。结果表明，CWP组的侵袭和迁移能力受到抑制。蛋白质免疫印迹法显示，CWP可降低Cox - 2的表达并抑制PI3K/AKT/GSK3/β - 连环蛋白信号通路。在动物实验中，我们观察到CWP对裸鼠异种移植瘤的生长有抑制作用。采用免疫组化法、酶联免疫吸附测定法、逆转录 - 聚合酶链反应法和蛋白质免疫印迹法检测Cox - 2/PGE2 - PI3K/AKT/GSK3/β - 连环蛋白通路的相关细胞因子。结果表明，CWP可抑制Cox - 2/PGE2 - PI3K/AKT/GSK3/β - 连环蛋白通路的相关细胞因子。综上所述，我们认为CWP通过Cox - 2/PGE2 - PI3K/AKT/GSK3/β - 连环蛋白信号通路抑制SGC - 7901细胞的侵袭和转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/8a307d85c86c/ECAM2017-3039450.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/5132aee12025/ECAM2017-3039450.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/0c267dc11570/ECAM2017-3039450.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/99cecc882386/ECAM2017-3039450.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/8dae565fc40f/ECAM2017-3039450.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/49f3b6922d73/ECAM2017-3039450.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/4b5b6ed9d419/ECAM2017-3039450.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/ccfeb136dc31/ECAM2017-3039450.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/855e6b6d3947/ECAM2017-3039450.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/8a307d85c86c/ECAM2017-3039450.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/5132aee12025/ECAM2017-3039450.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/0c267dc11570/ECAM2017-3039450.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/99cecc882386/ECAM2017-3039450.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/8dae565fc40f/ECAM2017-3039450.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/49f3b6922d73/ECAM2017-3039450.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/4b5b6ed9d419/ECAM2017-3039450.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/ccfeb136dc31/ECAM2017-3039450.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/855e6b6d3947/ECAM2017-3039450.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3547/5735682/8a307d85c86c/ECAM2017-3039450.009.jpg

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