Department of Pharmaceutical Sciences, Jefferson College of Pharmacy, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Biomed Res Int. 2017;2017:9363040. doi: 10.1155/2017/9363040. Epub 2017 Nov 20.
Glioblastoma multiforme (GBM) is the most frequent, primary malignant brain tumor prevalent in humans. GBM characteristically exhibits aggressive cell proliferation and rapid invasion of normal brain tissue resulting in poor patient prognosis. The current standard of care of surgical resection followed by radiotherapy and chemotherapy with temozolomide is not very effective. The inefficacy of the chemotherapeutic agents may be attributed to the challenges in drug delivery to the tumor. Several epidemiological studies have demonstrated the chemopreventive role of natural, dietary compounds in the development and progression of cancer. Many of these studies have reported the potential of using natural compounds in combination with chemotherapy and radiotherapy as a novel approach for the effective treatment of cancer. In this paper, we review the role of several natural compounds individually and in combination with chemotherapeutic agents in the treatment of GBM. We also assess the potential of drug delivery approaches such as the Gliadel wafers and role of nanomaterial based drug delivery systems for the effective treatment of GBM.
多形性胶质母细胞瘤（GBM）是最常见的原发性恶性脑肿瘤，在人类中普遍存在。GBM 的特征是具有侵袭性的细胞增殖和快速侵袭正常脑组织，导致患者预后不良。目前的治疗标准是手术切除，然后进行放疗和替莫唑胺化疗，但效果并不理想。化疗药物的疗效不佳可能归因于向肿瘤输送药物的挑战。几项流行病学研究表明，天然、饮食化合物在癌症的发生和发展中具有化学预防作用。其中许多研究报告了将天然化合物与化疗和放疗联合使用作为治疗癌症的有效新方法的潜力。在本文中，我们单独和联合化疗药物综述了几种天然化合物在治疗 GBM 中的作用。我们还评估了Gliadel 薄片等药物输送方法的潜力，以及基于纳米材料的药物输送系统在治疗 GBM 中的作用。
