Department of Respiratory Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
J Immunol Res. 2017;2017:3743048. doi: 10.1155/2017/3743048. Epub 2017 Nov 22.
Asthma is a chronic inflammatory disease that undermines the airways. It is caused by dysfunction of various types of cells, as well as cellular components, and is characterized by recruitment of inflammatory cells, bronchial hyperreactivity, mucus production, and airway remodelling and narrowing. It has commonly been considered that airway inflammation is caused by the Th2 immune response, or eosinophilia, which is a hallmark of bronchial asthma pathogenesis. Some patients display a neutrophil-dominant presentation and are characterized with low (or even absent) Th2 cytokines. In recent years, increasing evidence has also suggested that neutrophils play a key role in the development of certain subtypes of asthma. This review discusses neutrophils in asthma and potentially related targeted therapies.
哮喘是一种慢性炎症性疾病，会损害气道。它是由各种类型的细胞以及细胞成分功能障碍引起的，其特征是炎症细胞募集、支气管高反应性、黏液产生以及气道重塑和变窄。通常认为气道炎症是由 Th2 免疫反应或嗜酸性粒细胞引起的，这是支气管哮喘发病机制的一个标志。一些患者表现出以中性粒细胞为主的表现，其特点是 Th2 细胞因子水平低（甚至缺乏）。近年来，越来越多的证据表明中性粒细胞在某些亚型哮喘的发展中发挥关键作用。本文讨论了哮喘中的中性粒细胞以及潜在的相关靶向治疗。
