Häcki M
Schweiz Med Wochenschr. 1986 Jan 11;116(2):42-4.
Five patients are reported who experienced amnestic episodes a short time after oral intake of the recommended dose (7.5-15 mg) of the new benzodiazepine hypnotic midazolam. Patients were able to perform complex activities or to talk freely with other persons, and seemed to be awake and attentive. However, next morning they had complete andero-grade amnesia from intake of the drug. No other psychotropic medication or alcohol was involved. This type of drug-induced amnesia seems to be more frequent than so far reported, since all these episodes were observed in fewer than 30 cases in which the drug was prescribed. This means a considerable risk for patients and for others, and serious questions arise which should be carefully investigated.
报告了5例患者，他们在口服推荐剂量（7.5 - 15毫克）的新型苯二氮䓬类催眠药咪达唑仑后不久出现遗忘发作。患者能够进行复杂活动或与他人自由交谈，看起来清醒且专注。然而，第二天早上，他们对服药后的事情完全顺行性遗忘。未涉及其他精神药物或酒精。这种药物引起的遗忘症似乎比迄今报道的更为常见，因为在开具该药物的不到30例病例中观察到了所有这些发作。这对患者和他人意味着相当大的风险，并且出现了一些严重问题，应仔细调查。
