Fite J Judd, Ali Syed Z, VandenBussche Christopher J
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Diagn Cytopathol. 2018 Jul;46(7):600-603. doi: 10.1002/dc.23892. Epub 2018 Jan 23.
Pancreatic neuroendocrine tumors (PanNETs) are uncommon neoplasms that conventionally possess architectural and cytomorphological features seen in neuroendocrine neoplasms found at other sites. When present, these features often allow rapid identification of neuroendocrine differentiation and an accurate diagnosis. Here, we report the cytologic findings seen on fine-needle aspiration (FNA) of a PanNET with distinct rhabdoid features. This morphology is rare in PanNETs and has been reported in only two case series examining surgical resection specimens and has not been described on FNA. It is important to recognize this morphology as this variant appears to portend an aggressive clinical course. Furthermore, unfamiliarity with this morphologic variant may lead to a larger initial differential and thus delay final diagnosis.
胰腺神经内分泌肿瘤（PanNETs）是一种罕见的肿瘤，通常具有在其他部位发现的神经内分泌肿瘤中所见的结构和细胞形态学特征。当这些特征存在时，往往有助于快速识别神经内分泌分化并做出准确诊断。在此，我们报告了一例具有明显横纹肌样特征的PanNET细针穿刺抽吸（FNA）的细胞学发现。这种形态在PanNETs中罕见，仅在两个检查手术切除标本的病例系列中有报道，而FNA方面尚未见描述。认识到这种形态很重要，因为这种变体似乎预示着侵袭性的临床病程。此外，对这种形态变体不熟悉可能导致最初的鉴别诊断范围更大，从而延迟最终诊断。
