广泛期小细胞肺癌患者不同转移模式的预后分析：一项大型基于人群的研究。
The prognostic analysis of different metastatic patterns in extensive-stage small-cell lung cancer patients: a large population-based study.
机构信息
School of Medicine & Life Sciences, University of Jinan - Shandong Academy of Medical Sciences, Jinan, PR China.
Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, PR China.
出版信息
Future Oncol. 2018 Jun;14(14):1397-1407. doi: 10.2217/fon-2017-0706. Epub 2018 Jan 23.
AIM
To analyze the metastasis patterns and prognosis differences for extensive-stage small-cell lung cancer patients.
METHODS
Log-rank tests were used to calculate and compare survival estimates. Cox regression analyses were used to evaluate the prognosis factors.
RESULTS
The liver was the most common metastatic site, and lung was the least common. In two metastatic sites, liver and bone metastases were the most common combination of sites. An isolated liver metastasis had the worst overall survival (OS) and cancer-specific survival (CSS) among metastatic sites (both p < 0.001). Liver and lung metastases were associated with worse CSS (p < 0.039) and OS (p < 0.015). However, for patients with three metastatic sites showed no statistical differences in their CSS and OS (all, p > 0.05).
CONCLUSION
Extensive-stage small-cell lung cancer patients with metastasis to the liver alone or in combination with other organs appear to have worse outcomes.
目的
分析广泛期小细胞肺癌患者的转移模式和预后差异。
方法
采用对数秩检验计算并比较生存估计，采用 Cox 回归分析评估预后因素。
结果
肝脏是最常见的转移部位，肺部是最不常见的转移部位。在两个转移部位中，肝脏和骨转移是最常见的组合部位。孤立性肝转移在转移部位中总生存（OS）和癌症特异性生存（CSS）最差（均 p<0.001）。肝肺转移与 CSS 较差（p<0.039）和 OS 较差（p<0.015）相关。然而，对于转移部位达到三个的患者，CSS 和 OS 无统计学差异（均 p>0.05）。
结论
广泛期小细胞肺癌患者仅有肝转移或与其他器官转移相结合，其预后似乎更差。
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