Zhang Huimin, Gao Jie, Cong Xiaofeng, Chen Chen, Yin Jiaxin, Xiong Wenji, Liu Ziling
Cancer Center, The First Hospital of Jilin University, Changchun, China.
Department of Radiology, The First Hospital of Jilin University, Changchun, China.
Front Oncol. 2024 Oct 16;14:1403260. doi: 10.3389/fonc.2024.1403260. eCollection 2024.
Pancreatic metastasis is a rare malignant tumor; when it comes to multiple cancers, it may be a challenge to identify the primary lesion of new pancreatic metastases. With the continuous advancement of imaging technology, the PET/computed tomography (CT) has been widely used because of its high diagnostic accuracy and non-invasiveness. However, in the present case, the patient had history of limited small-cell lung carcinoma and prostatic cancer; the combined application of the three kinds of PET/CT was used to identify the new metastases of pancreatic and bone metastases, which suggested a high probability of primary G2 pancreatic neuroendocrine tumor with bone metastases. After the needle biopsy, samples were confirmed by diagnostic pathology as small-cell lung cancer metastasizing to the pancreas and bone. The results of our case suggests the irreplaceability of pathology and possibility of misdiagnosis by PET/CT; moreover, it also supplements clinical data for second primary cancers after small-cell lung cancer.
胰腺转移瘤是一种罕见的恶性肿瘤；当涉及多种癌症时，识别新的胰腺转移瘤的原发灶可能具有挑战性。随着成像技术的不断进步，正电子发射断层显像/计算机断层扫描（PET/CT）因其高诊断准确性和非侵入性而被广泛应用。然而，在本病例中，患者有局限性小细胞肺癌和前列腺癌病史；联合应用三种PET/CT来识别胰腺和骨转移的新转移灶，提示原发性G2胰腺神经内分泌肿瘤伴骨转移的可能性很大。经穿刺活检后，诊断病理证实样本为小细胞肺癌转移至胰腺和骨。我们病例的结果表明了病理学的不可替代性以及PET/CT误诊的可能性；此外，它还补充了小细胞肺癌后第二原发性癌症的临床数据。
