Camargo Jose F, Simkins Jacques, Schain Denise C, Gonzalez A Adrian, Alcaide Maria L, Anjan Shweta, Guerra Giselle, Roth David, Kupin Warren L, Mattiazzi Adela, Tan Yaohong, Milikowski Clara, Morris Michele I, Abbo Lilian M
Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Medicine, Division of Infectious Diseases, University of Florida School of Medicine, Gainesville, FL, USA.
Transpl Infect Dis. 2018 Apr;20(2):e12836. doi: 10.1111/tid.12836. Epub 2018 Feb 12.
Donor-derived infections (DDIs) are a very rare but potentially devastating complication of solid organ transplantation. Here we present a cluster of proven donor-derived cryptococcal infection in the kidney, liver, and lung recipients from a single donor. Remarkably, the onset of illness in the kidney and liver recipients occurred more than 8-12 weeks after transplantation, which is beyond the incubation period previously reported for donor-derived cryptococcosis. DDI should always be considered in the differential diagnosis of transplant recipients admitted with febrile illness, even when presenting beyond the first month post-transplant. Communication between reference laboratories, transplant centers, and organ procurement organizations is critical to improve outcomes.
供体源性感染（DDIs）是实体器官移植中一种非常罕见但可能具有毁灭性的并发症。在此，我们报告了一例来自单一供体的经证实的肾、肝和肺移植受者发生供体源性隐球菌感染的病例群。值得注意的是，肾和肝移植受者的发病时间在移植后8 - 12周以上，这超出了先前报道的供体源性隐球菌病的潜伏期。对于因发热性疾病入院的移植受者，即使在移植后第一个月以后出现症状，在鉴别诊断时也应始终考虑DDI。参考实验室、移植中心和器官采购组织之间的沟通对于改善治疗结果至关重要。
