在移植物失败后的第二次脐带血移植期间，预防性应用米卡芬净时出现皮肤外瓶霉突破性感染。
Breakthrough Exophiala dermatitidis infection during prophylactic administration of micafungin during second umbilical cord blood transplantation after graft failure.
作者信息
Watanabe Naoki, Gotoh Akihiko, Shirane Shuichi, Hamano Yasuharu, Hirai Yuji, Shimizu Maika, Nakamura Ayako, Matsumoto Kana, Morita Kunihiko, Mori Takeshi, Ohsaka Akimichi, Komatsu Norio
机构信息
Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Department of General Medicine, Faculty of Medicine, Juntendo University, Tokyo, Japan.
出版信息
Transpl Infect Dis. 2018 Apr;20(2):e12833. doi: 10.1111/tid.12833. Epub 2018 Feb 12.
Exophiala dermatitidis infections in patients with hematological malignancies are very rare. Our patient had a blood stream infection caused by E. dermatitidis following the second umbilical cord blood transplantation (UCBT) after graft failure during the first UCBT. To our knowledge, this is the first report describing a breakthrough fungal infection caused by E. dermatitidis during the prophylactic administration of micafungin (MCFG). Therefore, MCFG-treated patients should be monitored for breakthrough E. dermatitidis infection during hematopoietic stem cell transplantation.
皮肤外瓶霉感染在血液系统恶性肿瘤患者中非常罕见。我们的患者在第一次脐带血移植（UCBT）移植失败后进行第二次UCBT后发生了由皮肤外瓶霉引起的血流感染。据我们所知，这是第一份描述在预防性使用米卡芬净（MCFG）期间发生由皮肤外瓶霉引起的突破性真菌感染的报告。因此，在造血干细胞移植期间，应对接受MCFG治疗的患者监测是否发生皮肤外瓶霉突破性感染。
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