Kılıç Sarah S, Kılıç Suat, Crippen Meghan M, Varughese Denny, Eloy Jean Anderson, Baredes Soly, Mahmoud Omar M, Park Richard Chan Woo
Department of Radiation Oncology, Rutgers New Jersey Medical School, Newark, New Jersey.
Department of Otolaryngology - Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey.
Head Neck. 2018 Apr;40(4):828-836. doi: 10.1002/hed.25065. Epub 2018 Jan 23.
Few studies have examined the frequency and survival implications of clinicopathologic stage discrepancy in oral cavity squamous cell carcinoma (SCC).
Oral cavity SCC cases with full pathologic staging information were identified in the National Cancer Database (NCDB). Clinical and pathologic stages were compared. Multivariate logistic regressions were performed to identify factors associated with stage discrepancy.
There were 9110 cases identified, of which 67.3% of the cases were stage concordant, 19.9% were upstaged, and 12.8% were downstaged. The N classification discordance (28.5%) was more common than T classification discordance (27.6%). In cases of T classification discordance, downstaging is more common than upstaging (15.4% vs 12.1% of cases), but in cases of N classification discordance, the reverse is true; upstaging is much more common than downstaging (20.1 vs 8.4% of cases).
Clinicopathologic stage discrepancy in oral cavity SCC is a common phenomenon that is associated with a number of clinical factors and has survival implications.
很少有研究探讨口腔鳞状细胞癌（SCC）中临床病理分期差异的频率及其对生存的影响。
在国家癌症数据库（NCDB）中识别出具有完整病理分期信息的口腔SCC病例。比较临床分期和病理分期。进行多因素逻辑回归分析以确定与分期差异相关的因素。
共识别出9110例病例，其中67.3%的病例分期一致，19.9%的病例分期上调，12.8%的病例分期下调。N分类不一致（28.5%）比T分类不一致（27.6%）更常见。在T分类不一致的病例中，分期下调比分期上调更常见（分别为病例的15.4%和12.1%），但在N分类不一致的病例中情况相反；分期上调比分期下调更常见（分别为病例的20.1%和8.4%）。
口腔SCC中的临床病理分期差异是一种常见现象，与多种临床因素相关，并对生存有影响。
