Department of Otolaryngology-Head & Neck Surgery, Keimyung University Dongsan Medical Center, Daegu, South Korea.
Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Head Neck. 2018 Nov;40(11):2340-2346. doi: 10.1002/hed.25331. Epub 2018 Oct 10.
This study analyzed the expression of CD44 and cystine-glutamate transporter SLC7A11 (xCT) in primary oral cavity squamous cell carcinoma (SCC) and the relationships of expression to tumor recurrence and patient survival.
Associations between CD44 and xCT expression and clinicopathologic results were analyzed in 231 patients with oral cavity SCC. Cox proportional hazard analyses were used to identify factors associated with recurrence-free survival (RFS), disease-specific survival (DSS), and overall survival (OS).
Overexpression of CD44 and/or xCT was associated with advanced T classification, perineural invasion, and lymphovascular invasion (P < .05 each). High expression of xCT was also associated with nodal metastasis and depth of invasion (P < .01 each). Multivariate analysis indicated that high expression of xCT and both xCT and CD44 were independent predictors of poor RFS, DSS, and OS (P < .05 each).
Overexpression of xCT or xCT plus CD44 may predict posttreatment recurrence and survival in patients with oral cavity SCC.
本研究分析了 CD44 和胱氨酸-谷氨酸转运体 SLC7A11（xCT）在原发性口腔鳞状细胞癌（SCC）中的表达，以及其表达与肿瘤复发和患者生存的关系。
分析了 231 例口腔 SCC 患者中 CD44 和 xCT 表达与临床病理结果的关系。采用 Cox 比例风险分析确定与无复发生存（RFS）、疾病特异性生存（DSS）和总生存（OS）相关的因素。
CD44 和/或 xCT 的过度表达与 T 分类晚期、神经周围侵犯和血管淋巴管侵犯有关（P <.05 各）。xCT 的高表达也与淋巴结转移和浸润深度有关（P <.01 各）。多变量分析表明，xCT 高表达以及 xCT 和 CD44 均是口腔 SCC 患者 RFS、DSS 和 OS 不良的独立预测因素（P <.05 各）。
xCT 或 xCT 加 CD44 的过度表达可能预测口腔 SCC 患者治疗后复发和生存。
