College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science , 333 Longteng Road, Shanghai 201620, China.
Department of Biochemistry, University of Washington , 1705 NE Pacific Street, Seattle, Washington 98195, United States.
Org Lett. 2018 Feb 2;20(3):522-525. doi: 10.1021/acs.orglett.7b03593. Epub 2018 Jan 23.
Direct reaction of isocyanides with some sulfenic-acid-generating sulfoxides led to the effective formation of the corresponding thiocarbamic acid S-esters in good to high yields. A multicomponent reaction involving isocyanide, sulfoxide, and a suitable nucleophile has also been developed, providing ready access to a diverse range of sulfur-containing compounds, including isothioureas, carbonimidothioic acid esters, and carboximidothioic acid esters.
异氰化物与一些生成亚磺酸的亚砜直接反应，以良好至高产率有效地形成相应的硫代氨基甲酸硫酯。还开发了一种涉及异氰化物、亚砜和合适亲核试剂的多组分反应，为包括异硫脲、碳二亚胺硫酯和羧基硫代氨基甲酸酯在内的各种含硫化合物提供了简便的合成途径。
