College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, China.
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, China; Research Center of Analysis and Measurement, Zhejiang University of Technology, Hangzhou, 310014, China.
Chemosphere. 2018 Apr;197:299-305. doi: 10.1016/j.chemosphere.2018.01.046. Epub 2018 Jan 12.
The succinate dehydrogenase inhibitor (SDHI) fungicides have been extensively used in agriculture, and some of their potential ecological risks to aquatic organisms have been demonstrated recently. Sedaxane (SDX) is a broad spectrum SDHI fungicide. Despite being extensively used in environment, little is known about its potential developmental effect in zebrafish embryo. This study examined the effects of which SDX triggered in zebrafish through embryonic development assessments. Results show that SDX induced mortality, hatch delay and failure in zebrafish embryos, which were concentration dependent. In addition, several developmental abnormalities were observed at 2 mg/L and higher concentrations, including edema, microcephaly, body deformation, and swim bladder not fully inflated. SDX exposure influenced reactive oxygen species, malondialdehyde, peroxidase, glutathione S-transferase, superoxide dismutase and glutathione in live larvae, which indicated that oxidative stress was caused in zebrafish. Furthermore, SDX induced decrease of succinate dehydrogenase activity in zebrafish larvae. These results provide toxicological data of SDX on developing zebrafish embryo, which could be help for further understanding the potential risk on the environment.
琥珀酸脱氢酶抑制剂（SDHI）杀菌剂已被广泛应用于农业，最近有研究表明，它们对水生生物存在一定的潜在生态风险。噻唑酰胺（SDX）是一种广谱 SDHI 杀菌剂。尽管它在环境中被广泛使用，但对其在斑马鱼胚胎中的潜在发育影响却知之甚少。本研究通过胚胎发育评估，研究了 SDX 在斑马鱼体内引发的影响。结果表明，SDX 可诱导斑马鱼胚胎的死亡率、孵化延迟和孵化失败，其作用呈浓度依赖性。此外，在 2mg/L 及更高浓度下，观察到几种发育异常，包括水肿、小头畸形、身体变形和鳔未完全充气。SDX 暴露会影响活幼虫中的活性氧、丙二醛、过氧化物酶、谷胱甘肽 S-转移酶、超氧化物歧化酶和谷胱甘肽，表明其在斑马鱼体内引发了氧化应激。此外，SDX 还会降低斑马鱼幼虫中琥珀酸脱氢酶的活性。这些结果为 SDX 对发育中的斑马鱼胚胎的毒性数据提供了参考，这有助于进一步了解其对环境的潜在风险。
