探索一氧化二氮作为情绪障碍的治疗方法：基本概念。
Exploring Nitrous Oxide as Treatment of Mood Disorders: Basic Concepts.
作者信息
Nagele Peter, Zorumski Charles F, Conway Charles
出版信息
J Clin Psychopharmacol. 2018 Apr;38(2):144-148. doi: 10.1097/JCP.0000000000000837.
Abstract
Nitrous oxide (laughing gas) has shown early promise as a rapidly acting antidepressant in patients with treatment-resistant major depression and is currently investigated in several clinical trials. Because nitrous oxide is rarely administered outside operating rooms or dental practices, most psychiatrists are not familiar with how nitrous oxide is administered in a medical setting and what regulations guide its use. The goal of this brief review was to educate psychiatrists about the basic concepts of nitrous oxide administration and pharmacology. Furthermore, common misconceptions about nitrous oxide will be discussed.
摘要
一氧化二氮（笑气）已初步显示出有望成为治疗难治性重度抑郁症患者的速效抗抑郁药，目前正在多项临床试验中进行研究。由于一氧化二氮很少在手术室或牙科诊所之外使用，大多数精神科医生并不熟悉在医疗环境中如何使用一氧化二氮以及指导其使用的规定。本简要综述的目的是让精神科医生了解一氧化二氮给药和药理学的基本概念。此外，还将讨论关于一氧化二氮的常见误解。
相似文献
1
Exploring Nitrous Oxide as Treatment of Mood Disorders: Basic Concepts.探索一氧化二氮作为情绪障碍的治疗方法：基本概念。
J Clin Psychopharmacol. 2018 Apr;38(2):144-148. doi: 10.1097/JCP.0000000000000837.
2
[Detection and prevention of nitrous oxide iatrogenic pollution in dental treatments].[牙科治疗中氧化亚氮医源性污染的检测与预防]
Zhonghua Kou Qiang Yi Xue Za Zhi. 2019 Apr 9;54(4):282-285. doi: 10.3760/cma.j.issn.1002-0098.2019.04.015.
3
Nitrous oxide (laughing gas) facilitates excitability in rat hippocampal slices through gamma-aminobutyric acid A receptor-mediated disinhibition.
Anesthesiology. 2005 Jan;102(1):230-4. doi: 10.1097/00000542-200501000-00034.
4
200 years of nitrous oxide (laughing gas)--and the end of an era?一氧化二氮（笑气）的两百年——以及一个时代的终结？
Anasthesiol Intensivmed Notfallmed Schmerzther. 2001 Oct;36(10):640. doi: 10.1055/s-2001-17681.
5
Nitrous oxide revisited: evidence for potent antihyperalgesic properties.氧化亚氮再探讨：强效抗痛觉过敏特性的证据。
Anesthesiology. 2005 Oct;103(4):845-54. doi: 10.1097/00000542-200510000-00024.
6
Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.一氧化二氮治疗难治性重度抑郁症：概念验证试验。
Biol Psychiatry. 2015 Jul 1;78(1):10-18. doi: 10.1016/j.biopsych.2014.11.016. Epub 2014 Dec 9.
7
The pharmacological basis of pain control in dental practice: nitrous oxide.
Compend Contin Educ Dent (Lawrenceville). 1981 Sep-Oct;2(5):271-4, 276.
8
Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures.一氧化二氮对海马神经元培养物中兴奋性和抑制性突触传递的影响。
J Neurosci. 1998 Dec 1;18(23):9716-26. doi: 10.1523/JNEUROSCI.18-23-09716.1998.
9
Nitrous oxide and xenon prevent amphetamine-induced carrier-mediated dopamine release in a memantine-like fashion and protect against behavioral sensitization.一氧化二氮和氙以美金刚样方式阻止苯丙胺诱导的载体介导的多巴胺释放，并预防行为敏化。
Biol Psychiatry. 2006 Jul 1;60(1):49-57. doi: 10.1016/j.biopsych.2005.10.007. Epub 2006 Jan 19.
引用本文的文献
1
Nitrous oxide induces subacute combined degeneration by affecting vitamin B12 metabolism.氧化亚氮通过影响维生素B12代谢导致亚急性联合变性。
Med Gas Res. 2024 Sep 1;14(3):142-144. doi: 10.4103/2045-9912.385941. Epub 2023 Sep 17.
2
Emerging Medications for Treatment-Resistant Depression: A Review with Perspective on Mechanisms and Challenges.治疗抵抗性抑郁症的新兴药物：机制与挑战视角的综述
Brain Sci. 2025 Feb 6;15(2):161. doi: 10.3390/brainsci15020161.
3
Immediate effects of propofol on mood: a randomized comparison of two doses in a cohort with depression.丙泊酚对情绪的即时影响：抑郁症队列中两种剂量的随机对照比较
Psychopharmacology (Berl). 2025 Mar;242(3):481-495. doi: 10.1007/s00213-024-06699-2. Epub 2024 Oct 17.
4
The role of neurotrophic factors in novel, rapid psychiatric treatments.神经营养因子在新颖、快速的精神科治疗中的作用。
Neuropsychopharmacology. 2024 Jan;49(1):227-245. doi: 10.1038/s41386-023-01717-x. Epub 2023 Sep 6.
5
The efficacy and tolerability of inhaled nitrous oxide in major depressive disorder: a systematic review and meta-analysis.吸入一氧化二氮治疗重性抑郁障碍的疗效和耐受性：系统评价和荟萃分析。
Psychopharmacology (Berl). 2023 Oct;240(10):2033-2043. doi: 10.1007/s00213-023-06449-w. Epub 2023 Aug 23.
6
Nitrous Oxide Reduced Suicidal Ideation in Treatment-Resistant Major Depression in Exploratory Analysis.在探索性分析中，一氧化二氮可减轻难治性重度抑郁症患者的自杀意念。
J Clin Psychiatry. 2023 Aug 16;84(5):22br14725. doi: 10.4088/JCP.22br14725.
7
Ketamine in neuropsychiatric disorders: an update.氯胺酮在神经精神疾病中的应用：最新进展。
Neuropsychopharmacology. 2024 Jan;49(1):23-40. doi: 10.1038/s41386-023-01632-1. Epub 2023 Jun 20.
8
Analysis of the relationship between tuberculosis-related mortality and nitrous oxide emission levels in the world with the environmental Kuznets curve method.用环境库兹涅茨曲线方法分析全球与一氧化二氮排放水平相关的结核病死亡率之间的关系。
Turk J Med Sci. 2022 Aug;52(4):1329-1335. doi: 10.55730/1300-0144.5439. Epub 2022 Aug 10.
9
What is better for psychiatry: Titrated or fixed concentrations of nitrous oxide?对于精神病学而言，哪种更好：滴定浓度还是固定浓度的一氧化二氮？
Front Psychiatry. 2022 Aug 22;13:773190. doi: 10.3389/fpsyt.2022.773190. eCollection 2022.
10
Nitrous Oxide, a Rapid Antidepressant, Has Ketamine-like Effects on Excitatory Transmission in the Adult Hippocampus.一氧化二氮，一种快速抗抑郁药，对成年海马体中的兴奋性传递具有类似氯胺酮的作用。
Biol Psychiatry. 2022 Dec 15;92(12):964-972. doi: 10.1016/j.biopsych.2022.06.016. Epub 2022 Jun 22.
本文引用的文献
1
Side-effects associated with ketamine use in depression: a systematic review.氯胺酮用于治疗抑郁症的副作用：一项系统评价
Lancet Psychiatry. 2018 Jan;5(1):65-78. doi: 10.1016/S2215-0366(17)30272-9. Epub 2017 Jul 27.
2
A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders.关于使用氯胺酮治疗心境障碍的共识声明。
JAMA Psychiatry. 2017 Apr 1;74(4):399-405. doi: 10.1001/jamapsychiatry.2017.0080.
3
The Subjective Response to Nitrous Oxide is a Potential Pharmaco-Endophenotype for Alcohol Use Disorder: A Preliminary Study with Heavy Drinkers.《氧化亚氮主观反应：酒精使用障碍的潜在药物内表型：一项针对重度饮酒者的初步研究》
Int J Neuropsychopharmacol. 2017 Apr 1;20(4):346-350. doi: 10.1093/ijnp/pyw063.
4
Nitrous Oxide, From the Operating Room to the Emergency Department.一氧化二氮，从手术室到急诊科
Curr Emerg Hosp Med Rep. 2016;4:11-18. doi: 10.1007/s40138-016-0092-3. Epub 2016 Mar 22.
5
Neurologic, psychiatric, and other medical manifestations of nitrous oxide abuse: A systematic review of the case literature.一氧化二氮滥用的神经、精神及其他医学表现：病例文献的系统评价
Am J Addict. 2016 Aug;25(5):358-69. doi: 10.1111/ajad.12372. Epub 2016 Apr 1.
6
Nitrous oxide speeds the reduction of distressing intrusive memories in an experimental model of psychological trauma.在心理创伤的实验模型中，一氧化二氮加速了令人痛苦的侵入性记忆的消退。
Psychol Med. 2016 Jun;46(8):1749-59. doi: 10.1017/S003329171600026X. Epub 2016 Mar 4.
7
Up: The rise of nitrous oxide abuse. An international survey of contemporary nitrous oxide use.向上：一氧化二氮滥用的兴起。当代一氧化二氮使用情况的国际调查。
J Psychopharmacol. 2016 Apr;30(4):395-401. doi: 10.1177/0269881116632375. Epub 2016 Feb 24.
8
Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy.难治性重度抑郁症：以N-甲基-D-天冬氨酸受体为靶点及一氧化二氮作为治疗手段的理论依据
Front Psychiatry. 2015 Dec 9;6:172. doi: 10.3389/fpsyt.2015.00172. eCollection 2015.
9
Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.一氧化二氮治疗难治性重度抑郁症：概念验证试验。
Biol Psychiatry. 2015 Jul 1;78(1):10-18. doi: 10.1016/j.biopsych.2014.11.016. Epub 2014 Dec 9.
10
N-methyl-D-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas.一氧化二氮气体类似 N-甲基-D-天冬氨酸受体通道阻滞剂的辨别刺激效应。
J Pharmacol Exp Ther. 2015 Jan;352(1):156-65. doi: 10.1124/jpet.114.218057. Epub 2014 Nov 3.
Zotero 插件