Lai Yi C, Yew Yik W
Harvard School of Public Health, Boston, Massachusetts, USA.
Harvard School of Public Health, Boston, Massachusetts, USA; and National Skin Centre, Singapore.
Cutis. 2017 Dec;100(6):E6-E20.
Lichen planus (LP) and lichenoid drug eruptions (LDEs) uncommonly occur after vaccination, especially for hepatitis B and influenza. The key initiating event that leads to the development of postimmunization LP or LDE is not well understood. There have been prior reports of an association between several vaccines and LP. In this study, we aim to characterize and review cases of LP and LDE after vaccination from the Vaccine Adverse Event Reporting System (VAERS) national database in the United States. Information on vaccine-associated LP and LDE was retrieved from the database (July 1990 to November 2014) to examine the frequency of LP or LDE after vaccination. Hepatitis B, influenza, and herpes zoster vaccines were the 3 most commonly associated vaccines. Patients with LP or LDE were significantly older compared to the reported adverse events (AEs) overall (P<.001). The median age of onset for LP and LDE was 47 years. The median time of onset of AEs was 14 days. It is important to obtain recent vaccination history in patients presenting with new-onset LP or LDE.
扁平苔藓（LP）和苔藓样药疹（LDE）在接种疫苗后很少发生，尤其是乙肝疫苗和流感疫苗。导致免疫接种后LP或LDE发生的关键起始事件尚未完全明确。此前已有数种疫苗与LP之间存在关联的报道。在本研究中，我们旨在对美国疫苗不良事件报告系统（VAERS）国家数据库中接种疫苗后发生LP和LDE的病例进行特征描述和回顾。从该数据库（1990年7月至2014年11月）中检索与疫苗相关的LP和LDE信息，以研究接种疫苗后LP或LDE的发生频率。乙肝疫苗、流感疫苗和带状疱疹疫苗是3种最常与之相关的疫苗。与总体报告的不良事件（AE）相比，LP或LDE患者的年龄显著更大（P<0.001）。LP和LDE的发病年龄中位数为47岁。AE的发病时间中位数为14天。对于出现新发LP或LDE的患者，获取近期接种史很重要。
