双能 CT 诊断骨骨髓水肿伴椎体压缩性骨折的准确性：Meta 分析。
Diagnostic accuracy of dual-energy computed tomography in bone marrow edema with vertebral compression fractures: A meta-analysis.
机构信息
Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, No.6 Jiefang Street, Dalian 116001, Liaoning Province, China.
Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, No.6 Jiefang Street, Dalian 116001, Liaoning Province, China.
出版信息
Eur J Radiol. 2018 Feb;99:124-129. doi: 10.1016/j.ejrad.2017.12.018. Epub 2017 Dec 21.
PURPOSE
This meta-analysis aimed to evaluate the diagnostic performance of dual-energy computed tomography (DECT) for the bone marrow edema (BME) in patients with vertebral compression fractures.
METHODS
The PubMed, EMBASE, and the Cochrane Library database were searched up to July 2017 for relevant original studies. Data were extracted to calculate the pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive and negative likelihood ratios (PLR and NLR), and areas under summary receiver operating characteristic (SROC) curves for analysis.
RESULTS
A total of seven studies including 510 vertebras were available for the meta-analysis. Overall pooled sensitivity and specificity of DECT for detecting BME were 0.82 (95%CI: 0.76-0.86) and 0.98 (95%CI: 0.97-0.99), respectively. The PLR was 29.74 (95%CI: 15.62-56.61), the NLR was 0.19 (95%CI: 0.11-0.33), and DOR was 201.96 (95%CI: 99.98-407.93). The SROC value was 0.978. In addition, a subgroup analysis was conducted according to the mean time interval between the DECT and MRI. In 5 studies with more than 2 days interval, the pooled sensitivity and specificity of DECT were 0.89 (95%CI: 0.84-0.93) and 0.98 (95%CI: 0.95-0.99), respectively. The AUC value was 0.979.
CONCLUSIONS
Current evidence of our meta-analysis indicates that DECT has a high diagnostic accuracy in BME of vertebral compression fractures. In addition, DECT may have a less sensitive in BME of hyper-acute period.
目的
本荟萃分析旨在评估双能 CT（DECT）对椎体压缩性骨折患者骨髓水肿（BME）的诊断性能。
方法
检索了 PubMed、EMBASE 和 Cochrane 图书馆数据库，截至 2017 年 7 月，以获取相关的原始研究。提取数据以计算汇总敏感性、特异性、诊断比值比（DOR）、阳性和阴性似然比（PLR 和 NLR）以及汇总受试者工作特征（SROC）曲线下面积，进行分析。
结果
共有 7 项研究，涉及 510 个椎体，可用于荟萃分析。DECT 检测 BME 的总体汇总敏感性和特异性分别为 0.82（95%CI：0.76-0.86）和 0.98（95%CI：0.97-0.99）。PLR 为 29.74（95%CI：15.62-56.61），NLR 为 0.19（95%CI：0.11-0.33），DOR 为 201.96（95%CI：99.98-407.93）。SROC 值为 0.978。此外，根据 DECT 和 MRI 之间的平均时间间隔进行了亚组分析。在 5 项间隔时间超过 2 天的研究中，DECT 的汇总敏感性和特异性分别为 0.89（95%CI：0.84-0.93）和 0.98（95%CI：0.95-0.99）。AUC 值为 0.979。
结论
本荟萃分析的现有证据表明，DECT 对椎体压缩性骨折的 BME 具有较高的诊断准确性。此外，DECT 在超急性期的 BME 可能不太敏感。
Zotero 插件