Bendix U, Bendix U
Allerg Immunol (Leipz). 1985;31(4):273-82.
We try to prepare tumor-associated antigens from human mammary carcinomas by the use of several biochemical methods and to detect the biologic activity of these antigens with the macrophage adherence inhibition assay. The diagnostic relevance of the macrophage adherence inhibition assay was to improve by optimal enrichment of the tumor-associated antigens. By the use of this test system an enrichment of tumor-associated antigens was not detectable. Our results show, that the macrophage adherence inhibition assay because of its low sensitivity (53%) and the insufficient reproducibility can not be used as test system for tumor immunity in human cancer.
我们尝试通过几种生化方法从人乳腺癌中制备肿瘤相关抗原，并利用巨噬细胞黏附抑制试验检测这些抗原的生物活性。通过对肿瘤相关抗原进行最佳富集来提高巨噬细胞黏附抑制试验的诊断相关性。使用该检测系统时，未检测到肿瘤相关抗原的富集。我们的结果表明，由于巨噬细胞黏附抑制试验灵敏度低（53%）且重复性不足，不能用作人类癌症肿瘤免疫的检测系统。
