Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia.
Centre for Molecular and Medical Research, School of Medicine, Deakin University, Waurn Ponds, VIC, Australia.
Mediators Inflamm. 2017;2017:7517350. doi: 10.1155/2017/7517350. Epub 2017 Dec 7.
Granulocyte colony-stimulating factor (G-CSF) was originally discovered in the context of hematopoiesis. However, the identification of the G-CSF receptor (G-CSFR) being expressed outside the hematopoietic system has revealed wider roles for G-CSF, particularly in tissue repair and regeneration. Skeletal muscle damage, including that following strenuous exercise, induces an elevation in plasma G-CSF, implicating it as a potential mediator of skeletal muscle repair. This has been supported by preclinical studies and clinical trials investigating G-CSF as a potential therapeutic agent in relevant disease states. This review focuses on the growing literature associated with G-CSF and G-CSFR in skeletal muscle under healthy and disease conditions and highlights the current controversies.
粒细胞集落刺激因子（G-CSF）最初是在造血过程中发现的。然而，G-CSF 受体（G-CSFR）在造血系统之外的表达的鉴定揭示了 G-CSF 的更广泛作用，特别是在组织修复和再生中。包括剧烈运动后在内的骨骼肌损伤会导致血浆 G-CSF 升高，这表明它可能是骨骼肌修复的潜在介质。这一观点得到了临床前研究和临床试验的支持，这些研究将 G-CSF 作为相关疾病状态下的一种潜在治疗药物进行了研究。本文综述了与健康和疾病状态下骨骼肌中的 G-CSF 和 G-CSFR 相关的不断增长的文献，并强调了当前的争议。
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