重度未控制哮喘患者中维生素D、炎症与肺功能的关系
Relationship between Vitamin D, Inflammation and Lung Function In Patients with Severe Uncontrolled Asthma.
作者信息
Janeva-Jovanovska Elena, Dokic Dejan, Jovkovska-Kaeva Biserka, Breskovska Gorica, Goseva Zlatica, Minov Jordan, Trajkov Dejan, Dimitrova-Genadieva Magdalena, Zafirovska-Ivanovska Beti
机构信息
PHI University Clinic of Pulmonology and Allergy, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
Institute for Occupational Health of RM - Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.
出版信息
Open Access Maced J Med Sci. 2017 Nov 19;5(7):899-903. doi: 10.3889/oamjms.2017.190. eCollection 2017 Dec 15.
BACKGROUND
Recently epidemiological studies showed that low vitamin D is linked to airway hyperresponsiveness, decreased lung function, poor asthma control, and steroid-resistant asthma.
AIM
We investigated the relationship between Vitamin D, inflammation with circulating IL-33 and lung function in 30 patients with severe uncontrolled asthma.
MATERIALS AND METHODS
The study included 30 patients with severe uncontrolled asthma. In each of them were measured serum levels of IL-33 and Vitamin D by the ELISA method. The pulmonary function is measured by basic spirometry parameters, FEV1. The results were statistically elaborated according to the Pearson's Correlation Tests.
RESULTS
The results showed statistically insignificant correlation between Vitamin D and IL-33, and Vitamin D with FEV1 (Vit.D/IL-33; r = 0.11323, p = 0.551); (Vit.D/FEV1; r = -0.1005; p = 0.597) Correlation between IL-33 and FEV1 is negative but statistically significant (IL-33/FEV1; r = -0.5248; p = 0.003).
CONCLUSION
Because there are little studies about the link between vitamin D and asthma, further research to clarify the mechanism how vitamin D control the activity of CD4+ T cells and the related Th2-type cytokines in the parthenogenesis of asthma.
背景
最近的流行病学研究表明，低维生素D与气道高反应性、肺功能下降、哮喘控制不佳和激素抵抗性哮喘有关。
目的
我们调查了30例严重未控制哮喘患者中维生素D、循环白细胞介素-33（IL-33）炎症与肺功能之间的关系。
材料与方法
该研究纳入30例严重未控制哮喘患者。通过酶联免疫吸附测定（ELISA）法测定他们每个人血清中的IL-33和维生素D水平。通过基本肺量计参数第一秒用力呼气容积（FEV1）测量肺功能。根据Pearson相关检验对结果进行统计学分析。
结果
结果显示维生素D与IL-33之间以及维生素D与FEV1之间的相关性在统计学上无显著意义（维生素D/IL-33；r = 0.11323，p = 0.551）；（维生素D/FEV1；r = -0.1005；p = 0.597）。IL-33与FEV1之间的相关性为负，但具有统计学意义（IL-33/FEV1；r = -0.5248；p = 0.003）。
结论
由于关于维生素D与哮喘之间联系的研究较少，需要进一步研究以阐明维生素D在哮喘发病过程中如何控制CD4 + T细胞活性及相关Th2型细胞因子的机制。
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