Tamašauskienė Laura, Gasiūnienė Edita, Lavinskienė Simona, Sakalauskas Raimundas, Šitkauskienė Brigita
Department of Pulmonology and Immunology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Department of Pulmonology and Immunology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Medicina (Kaunas). 2015;51(6):321-7. doi: 10.1016/j.medici.2015.11.003. Epub 2015 Nov 24.
Some researches show that low vitamin D may play a role in asthma pathogenesis. The aim of this study was to evaluate the serum vitamin D level in asthmatics with different phenotypes and to determine its associations with lung function, IgE, eosinophil count and body mass index (BMI).
The study population comprised 85 patients with asthma and 73 healthy persons. Patients with asthma were divided into groups according to phenotypes. Allergy was assessed using a skin prick test and measuring eosinophil count in peripheral blood and total IgE in serum. Lung function was evaluated by spirometry. Concentration of vitamin D (25(OH)D3) was measured using a commercial ELISA kit. Smoking history was assessed and BMI was calculated for all individuals.
The vitamin D level was lower in asthmatics than in the control group (14.36±0.57 vs. 22.13±0.84 ng/mL, P<0.01). There were no significant differences in the vitamin D level between the groups with allergic and non-allergic asthma (14.36±0.77 vs. 14.35±0.74 ng/mL). The low vitamin D level increased the risk of asthma 1.2 times (OR, 1.194; 95% CI, 1.109-1.286, P<0.01). The vitamin D level did not correlate with lung function and markers of allergy in asthmatic patients. The vitamin D level correlated with FEV1/FVC (rs=0.72, P<0.05) in smoking patients with asthma. Correlation between the vitamin D level and BMI was found in all studied subjects (rs=-0.18, P<0.05).
The vitamin D level was lower in asthmatic patients than in healthy individuals despite their hypersensitivity and increase risk of asthma. There was no relation between the vitamin D level and lung function, eosinophil count and total IgE level, whereas the lower vitamin D level was associated with higher BMI.
一些研究表明，低维生素D水平可能在哮喘发病机制中起作用。本研究旨在评估不同表型哮喘患者的血清维生素D水平，并确定其与肺功能、免疫球蛋白E（IgE）、嗜酸性粒细胞计数及体重指数（BMI）之间的关系。
研究对象包括85例哮喘患者和73名健康人。哮喘患者根据表型分组。通过皮肤点刺试验、外周血嗜酸性粒细胞计数及血清总IgE测定评估过敏情况。采用肺量计评估肺功能。使用商用酶联免疫吸附测定（ELISA）试剂盒测量维生素D（25羟维生素D3）浓度。评估所有个体的吸烟史并计算BMI。
哮喘患者的维生素D水平低于对照组（14.36±0.57对22.13±0.84 ng/mL，P<0.01）。过敏性哮喘组与非过敏性哮喘组之间的维生素D水平无显著差异（14.36±0.77对14.35±0.74 ng/mL）。低维生素D水平使哮喘风险增加1.2倍（比值比，1.194；95%置信区间，1.109 - 1.286，P<0.01）。哮喘患者的维生素D水平与肺功能及过敏标志物无相关性。在吸烟的哮喘患者中，维生素D水平与第一秒用力呼气容积/用力肺活量（FEV1/FVC）相关（rs = 0.72，P<0.05）。在所有研究对象中发现维生素D水平与BMI相关（rs = -0.18，P<0.05）。
尽管哮喘患者存在超敏反应且哮喘风险增加，但其维生素D水平低于健康个体。维生素D水平与肺功能、嗜酸性粒细胞计数及总IgE水平无关，而较低的维生素D水平与较高的BMI相关。
