Bugadze L, Manjavidze N, Jorjoliani L
David Aghmashenebeli University of Georgia, Tbilisi, Georgia.
Georgian Med News. 2018 Oct(283):115-118.
The aim of the study - low circulating vitamin D level maybe related to poor asthma control status and decreased lung function. The aim of our research is to establish correlation between serum vitamin D level, asthma control status and lung function. The study was performed in children aged 6-15 years old, including patients with asthma (n=50), who referred to Sachkhere medical center for a visit. The status of asthma control in the basic group was classified as controlled (n=31) and uncontrolled (n=19). The children underwent serum vitamin D and IgE level, spirometry and skin prick tests for the study. Using the multivariate logistic regression analysis, the presence of asthma was associated with the reduced level of vitamin D (OR = 1.35, 95% CI (1,14-1.58) P = 0.011; χ2=6.78; F-0.022) in children with uncontrolled bronchial asthma. 48% of the patients in the group- controlled asthma (n=15) had vitamin D deficit, and in 52% of the cases (n=16) was confirmed with vitamin D insufficient. In the group -uncontrolled asthma - 5% of the patients (n=1) had Vitamin D insufficiency in blood serum. In 95% (n=18) of the patients vitamin D level was significantly low <20 ng/ml. According the results, decreased pulmonary function (p-0.039; χ2-3.12) is strongly associated with low level of vitamin D; but neither serum IgE level (p-0.54; χ2-10.9), nor skin prick test result on dust mite (p-0.50, χ2-5.12 ) was correlations with serum vitamin D low level. The presence of vitamin D deficiency effectively predict increased risk of uncontrolled bronchial asthma in children. Serum vitamin D level is related to lung function too. Therefore, the normalization of the serum levels of Vitamin D may have beneficial effect on improvement of asthma control in the complex of asthma management and preventive measures.
该研究的目的——循环维生素D水平低可能与哮喘控制不佳及肺功能下降有关。我们研究的目的是建立血清维生素D水平、哮喘控制状态和肺功能之间的相关性。该研究在6至15岁的儿童中进行，包括前往萨奇赫雷医疗中心就诊的哮喘患者（n = 50）。基础组中哮喘控制状态分为控制良好（n = 31）和控制不佳（n = 19）。为进行该研究，这些儿童接受了血清维生素D和IgE水平检测、肺功能测定以及皮肤点刺试验。使用多因素逻辑回归分析，在支气管哮喘控制不佳的儿童中，哮喘的存在与维生素D水平降低相关（OR = 1.35，95% CI（1.14 - 1.58），P = 0.011；χ2 = 6.78；F = 0.022）。哮喘控制良好组（n = 15）中有48%的患者存在维生素D缺乏，52%的病例（n = 16）被证实维生素D不足。在哮喘控制不佳组中，5%的患者（n = 1）血清维生素D不足。95%（n = 18）的患者维生素D水平显著低于20 ng/ml。根据结果，肺功能下降（p = 0.039；χ2 = 3.12）与维生素D水平低密切相关；但血清IgE水平（p = 0.54；χ2 = 10.9）以及对尘螨的皮肤点刺试验结果（p = 0.50，χ2 = 5.12）均与血清维生素D低水平无关。维生素D缺乏的存在有效预测了儿童支气管哮喘控制不佳风险的增加。血清维生素D水平也与肺功能有关。因此，在哮喘管理和预防措施的综合方案中，血清维生素D水平的正常化可能对改善哮喘控制有有益作用。
