Lisak R P, Laramore C, Levinson A I, Zweiman B, Moskovitz A R
Ann Neurol. 1986 Jan;19(1):87-9. doi: 10.1002/ana.410190119.
We cultured blood mononuclear cells of patients with myasthenia gravis both with and without removal of T8 suppressor cells. The levels of synthesized antibodies to acetylcholine receptor and IgG as well as the frequency of immunoglobulin-secreting cells were all higher in pokeweed mitogen-stimulated cultures depleted of T8+ cells. Thus, autologous suppressor cells within the T8+ population exert some regulatory control over antiacetylcholine receptor-producing cells in patients with myasthenia gravis.
我们培养了重症肌无力患者的血液单核细胞，分为去除和未去除T8抑制细胞两组。在去除T8 +细胞的商陆有丝分裂原刺激培养物中，抗乙酰胆碱受体和IgG的合成抗体水平以及免疫球蛋白分泌细胞的频率均较高。因此，T8 +群体中的自体抑制细胞对重症肌无力患者中产生抗乙酰胆碱受体的细胞发挥了一定的调节控制作用。
