亨廷顿痴呆症和正常衰老过程中多巴胺的神经化学

Neurochemistry of dopamine in Huntington's dementia and normal aging.

作者信息

Stahl S M, Thiemann S, Faull K F, Barchas J D, Berger P A

出版信息

Arch Gen Psychiatry. 1986 Feb;43(2):161-4. doi: 10.1001/archpsyc.1986.01800020071009.

DOI:10.1001/archpsyc.1986.01800020071009

Abstract

We measured the dopamine metabolite homovanillic acid (HVA) in cerebrospinal fluid (CSF) before and after probenecid administration in normal controls and in patients with Huntington's disease. Baseline CSF HVA concentrations correlated positively with age in normal control subjects. Baseline CSF HVA concentrations were reduced in patients with Huntington's disease, and the degree of this reduction correlated with the severity of dementia and with the duration of disease. These results suggest that changes in the metabolism of dopamine by dopaminergic neurons may be associated with the dementia of Huntington's disease as well as with normal aging. These changes in dopaminergic functioning are apparently different in Huntington's disease than in normal aging and can be detected by measuring CSF HVA concentration.

摘要

我们在正常对照者和亨廷顿病患者中，测量了丙磺舒给药前后脑脊液（CSF）中的多巴胺代谢产物高香草酸（HVA）。正常对照者中，脑脊液HVA的基线浓度与年龄呈正相关。亨廷顿病患者脑脊液HVA的基线浓度降低，这种降低的程度与痴呆的严重程度和病程相关。这些结果表明，多巴胺能神经元对多巴胺代谢的改变可能与亨廷顿病的痴呆以及正常衰老有关。多巴胺能功能的这些变化在亨廷顿病中与正常衰老明显不同，并且可以通过测量脑脊液HVA浓度来检测。