亨廷顿舞蹈病和小舞蹈病中的高香草酸
Homovanilic acid in Huntington's disease and Sydenham's chorea.
作者信息
Cunha L, Oliveira C R, Diniz M, Amaral R, Conçalves A F, Pio-Abreu J
出版信息
J Neurol Neurosurg Psychiatry. 1981 Mar;44(3):258-61. doi: 10.1136/jnnp.44.3.258.
Homovanilic acid (HVA) was determined in the lumbar CSF of 12 patients with Huntington's disease and 12 with Sydenham's chorea before and after probenecid administration. The means of HVA concentration (basal and after probenecid) were lower in those with Huntington's disease than in controls, and were even lower in a sub-group characterised by increased tone and slowness of voluntary movement. There was no correlation between CSF HVA values and the severity of abnormal movements, nor with length of the illness and age of the patients with Huntington's disease. The mean basal HVA concentration did not differ from controls in those with Sydenham's chorea but the accumulation with probenecid was significantly lower. These results suggest a decrease in cerebral dopamine release in both forms of chorea.
在12例亨廷顿舞蹈症患者和12例 Sydenham 舞蹈症患者的腰椎脑脊液中，在服用丙磺舒前后测定了高香草酸（HVA）。亨廷顿舞蹈症患者的 HVA 浓度均值（基础值和服用丙磺舒后）低于对照组，在以肌张力增高和自主运动迟缓为特征的亚组中更低。脑脊液 HVA 值与异常运动的严重程度之间没有相关性，也与亨廷顿舞蹈症患者的病程长短和年龄无关。Sydenham 舞蹈症患者的基础 HVA 浓度均值与对照组无差异，但丙磺舒后的蓄积量明显更低。这些结果表明两种舞蹈症形式中脑多巴胺释放均减少。
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