García Ruiz P J, Mena M A, Sanchez Bernardos V, Díaz Neira W, Gimenez Roldan S, Benitez J, García de Yebenes J
Department of Neurology, Fundación Jimenez Díaz, Madrid, Spain.
Clin Neuropharmacol. 1995 Feb;18(1):58-63. doi: 10.1097/00002826-199502000-00007.
We measured homovanillic acid (HVA), 5-hydroxy indole acetic acid (5-HIAA), and tryptophan (TP) in cerebrospinal fluid (CSF) of 20 neuroleptic-free patients with Huntington's disease (HD), and compared mean values with those from four control groups including 15 normal individuals, 38 patients with dystonia, 23 untreated patients with Parkinson's disease, and 61 patients with other neurological diseases (ONDs). The mean levels of HVA in the CSF of patients with HD were reduced compared with those from normal controls (p < 0.001), dystonic patients (p < 0.005), individuals with ONDs (p < 0.0001), and even from untreated parkinsonian patients (p < 0.05). 5-HIAA and TP levels in the CSF of patients with HD were not significantly different from those in the CSF of control patients. Our data suggest a reduced dopamine neurotransmission in HD and may account for the bradykinesia observed in our patients.
我们检测了20例未服用抗精神病药物的亨廷顿舞蹈病（HD）患者脑脊液（CSF）中的高香草酸（HVA）、5-羟吲哚乙酸（5-HIAA）和色氨酸（TP），并将平均值与四个对照组进行比较，这四个对照组包括15名正常个体、38例肌张力障碍患者、23例未接受治疗的帕金森病患者以及61例患有其他神经系统疾病（ONDs）的患者。与正常对照组（p < 0.001）、肌张力障碍患者（p < 0.005）、患有ONDs的个体（p < 0.0001）甚至未接受治疗的帕金森病患者（p < 0.05）相比，HD患者脑脊液中HVA的平均水平降低。HD患者脑脊液中5-HIAA和TP水平与对照患者脑脊液中的水平无显著差异。我们的数据表明HD患者存在多巴胺神经传递减少的情况，这可能是我们所观察到的患者运动迟缓的原因。
