多发性硬化症中与认知衰退相关的纵向人格变化。
Longitudinal personality change associated with cognitive decline in multiple sclerosis.
作者信息
Roy Shumita, Drake Allison, Fuchs Tom, Dwyer Michael G, Zivadinov Robert, Chapman Benjamin P, Weinstock-Guttman Bianca, Benedict Ralph Hb
机构信息
Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York (SUNY), Buffalo, NY, USA.
Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York (SUNY), Buffalo, NY, USA/Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York (SUNY), Buffalo, NY, USA.
出版信息
Mult Scler. 2018 Jan 1:1352458517753720. doi: 10.1177/1352458517753720.
We previously reported that personality and cognition were stable over 3 years in patients with multiple sclerosis (MS). This study examined whether a longer duration would reveal evidence of emerging personality dysfunction. The NEO Five-Factor Inventory and Brief International Cognitive Assessment for MS was used to assess personality and cognition, respectively. Patients were classified as "Cog Stable" or "Cog Decline" based on cognitive deterioration over 5 years. Extraversion and Conscientiousness declined across pooled groups. Follow-up of a group by time interaction found that decline in these traits was more evident in the Cog Decline group, demonstrating a link between personality and cognitive change.
我们之前报道过，多发性硬化症（MS）患者的人格和认知在3年时间里保持稳定。本研究旨在探讨更长的时间跨度是否会揭示出新出现的人格功能障碍迹象。分别使用NEO五因素人格量表和多发性硬化症简短国际认知评估量表来评估人格和认知。根据5年期间的认知衰退情况，将患者分为“认知稳定”或“认知衰退”两类。外向性和尽责性在合并组中有所下降。通过时间交互作用对一组患者进行随访发现，这些特质的下降在认知衰退组中更为明显，表明人格与认知变化之间存在联系。
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