Potticary Hannah, Langdon Dawn
Department of Psychology, Royal Holloway, University of London, Egham, Surrey TW20 0EX, UK.
J Clin Med. 2023 Jan 16;12(2):703. doi: 10.3390/jcm12020703.
Cognitive impairment is a prevalent and debilitating symptom of multiple sclerosis (MS) but is not routinely addressed in clinical care. The Brief Cognitive Assessment for Multiple Sclerosis (BICAMS) was developed in 2012 to screen and monitor MS patients’ cognition. This systematic review and meta-analysis aimed to identify, synthesise, and critically appraise current BICAMS’ international validations. The literature search was conducted using PubMed, PsycINFO and Web of Science electronic databases in August 2022. Quantitative, peer-reviewed adult studies, which followed the BICAMS international validation protocol and were published in English, were included. The search identified a total of 203 studies, of which 26 were eligible for inclusion. These reported a total of 2833 adults with MS and 2382 healthy controls (HC). The meta-analysis showed that BICAMS identified impaired cognitive functioning in adults with MS compared to HC for all three subtests: information processing speed (g = 0.854, 95% CI = 0.765, 0.944, p < 0.001), immediate verbal recall (g = 0.566, 95% CI = 0.459, 0.673, p < 0.001) and immediate visual recall (g = 0.566, 95% CI = 0.487, 0.645, p < 0.001). Recruitment sites and strategies limit the generalisability of results. BICAMS is a valid and feasible international MS cognitive assessment.
认知障碍是多发性硬化症（MS）常见且使人衰弱的症状，但在临床护理中并未得到常规处理。多发性硬化症简易认知评估量表（BICAMS）于2012年制定，用于筛查和监测MS患者的认知情况。本系统评价和荟萃分析旨在识别、综合并严格评估当前BICAMS的国际验证情况。2022年8月，我们使用PubMed、PsycINFO和Web of Science电子数据库进行了文献检索。纳入了遵循BICAMS国际验证方案并以英文发表的定量、同行评审的成人研究。检索共确定了203项研究，其中26项符合纳入标准。这些研究共报告了2833例成年MS患者和2382例健康对照（HC）。荟萃分析表明，在所有三个子测试中，与HC相比，BICAMS均能识别出MS成人患者存在认知功能受损：信息处理速度（g = 0.854，95%CI = 0.765，0.944，p < 0.001）、即刻言语回忆（g = 0.566，95%CI = 0.459，0.673，p < 0.001）和即刻视觉回忆（g = 0.566，95%CI = 0.487，0.645，p < 0.001）。招募地点和策略限制了结果的普遍性。BICAMS是一种有效且可行的国际MS认知评估工具。
