Simoni Amalie Højmose, Jerwiarz Anne, Randers Amalie, Gazerani Parisa
a Department of Health Science and Technology , Faculty of Medicine, Aalborg University , Aalborg East , Denmark.
Somatosens Mot Res. 2017 Dec;34(4):258-264. doi: 10.1080/08990220.2018.1425675. Epub 2018 Jan 24.
Pain perception is associated with different phenotypic characteristics such as sex, eye, and hair color. Hence, it is assumed that ABO blood type can also affect pain perception.
In order to investigate this hypothesis, an experimental study with healthy volunteers (18-40 years) was designed. The experimental procedure included a blood type test and two rounds of pressure pain threshold assessments separated by a cold pressor test. Pressure pain threshold was assessed bilaterally at the temporalis, masseter, and deltoid muscles, where the muscle sites were randomized. Cold pressor test was conducted by immersion of participants' non-dominant hand into iced water of 1-4 °C for 2 min.
Thirty-seven healthy volunteers, distributed in the four blood type groups, completed the study. Participants with blood type B scored the highest pressure pain thresholds at the examined craniofacial muscles, while participants with blood type AB tended to score the lowest. Furthermore, participants with blood type AB displayed the highest elevation in pressure pain thresholds after cold pressor test.
Participants with blood type B displayed the lowest mechanical pain sensitivity and the blood type AB group exhibited the strongest conditioned pain modulation effect. These findings emphasize the necessity of considering ABO blood types in future pain research.
疼痛感知与不同的表型特征相关，如性别、眼睛和头发颜色。因此，假定ABO血型也会影响疼痛感知。
为了研究这一假设，设计了一项针对健康志愿者（18 - 40岁）的实验研究。实验过程包括血型检测以及两轮压力疼痛阈值评估，两轮评估之间间隔一次冷加压试验。在颞肌、咬肌和三角肌双侧评估压力疼痛阈值，肌肉部位随机选取。冷加压试验通过将参与者的非优势手浸入1 - 4°C的冰水中2分钟来进行。
分布在四个血型组的37名健康志愿者完成了研究。B型血参与者在所检测的颅面部肌肉处的压力疼痛阈值得分最高，而AB型血参与者的得分往往最低。此外，AB型血参与者在冷加压试验后压力疼痛阈值的升高幅度最大。
B型血参与者表现出最低的机械性疼痛敏感性，而AB型血组表现出最强的条件性疼痛调制效应。这些发现强调了在未来疼痛研究中考虑ABO血型的必要性。
