实验性甲状腺功能亢进和甲状腺功能减退时心房及血浆中的心房利钠多肽

Atrial natriuretic polypeptide in atria and plasma in experimental hyperthyroidism and hypothyroidism.

作者信息

Kohno M, Takaori K, Matsuura T, Murakawa K, Kanayama Y, Takeda T

出版信息

Biochem Biophys Res Commun. 1986 Jan 14;134(1):178-83. doi: 10.1016/0006-291x(86)90544-9.

Abstract

To investigate the involvement of thyroid hormone on the release of atrial natriuretic polypeptide (ANP), we have measured immunoreactive ANP in the atria and plasma of experimental hyperthyroid and hypothyroid rats. Plasma ANP was higher (p less than 0.05) in hyperthyroid rats and was lower (p less than 0.05) in hypothyroid rats than in euthyroid rats. ANP content and concentration in the atria were lower (p less than 0.01) in hyperthyroid rats than in hypothyroid rats. An inverse correlation was found between the plasma ANP and ANP concentration in the atria (n = 15, r = 0.60, p less than 0.01). The results indicate an increased systemic release of ANP from the atria in hyperthyroidism and a decreased systemic release in hypothyroidism.

摘要

为研究甲状腺激素对心房利钠多肽（ANP）释放的影响，我们检测了实验性甲状腺功能亢进和甲状腺功能减退大鼠心房及血浆中的免疫反应性ANP。甲状腺功能亢进大鼠的血浆ANP水平高于正常甲状腺大鼠（p<0.05），而甲状腺功能减退大鼠的血浆ANP水平低于正常甲状腺大鼠（p<0.05）。甲状腺功能亢进大鼠心房中的ANP含量和浓度低于甲状腺功能减退大鼠（p<0.01）。血浆ANP与心房中ANP浓度呈负相关（n = 15，r = 0.60，p<0.01）。结果表明，甲状腺功能亢进时心房ANP的全身释放增加，而甲状腺功能减退时全身释放减少。