Kohno M, Horio T, Yasunari K, Yokokawa K, Ikeda M, Kurihara N, Nishizawa Y, Morii H, Takeda T
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Metabolism. 1993 Aug;42(8):1059-64. doi: 10.1016/0026-0495(93)90023-h.
This study was designed to examine the involvement of thyroid hormone in the release of brain natriuretic peptide (BNP) from the heart. We measured plasma immunoreactive BNP (ir-BNP) concentrations in patients with untreated hyperthyroidism. We also measured BNP values in experimental rats with hyperthyroidism induced by thyroxine (T4) and in rats with hypothyroidism induced by propylthiouracil (PTU). The in vitro effects of triiodothyronine (T3) and T4 on the release of BNP were examined in newborn rat atrial and ventricular myocytes in primary culture. Plasma BNP levels were increased in hyperthyroid patients compared with normal control subjects. Plasma BNP levels were increased in hyperthyroid rats and decreased in hypothyroid rats compared with euthyroid rats. Plasma BNP level was correlated with serum T4 level in hyperthyroid patients and hyperthyroid rats. A major component of ir-BNP in plasma from hyperthyroid patients was human BNP-32 and that in plasma from hyperthyroid rats was rat BNP-45. T4 and T3 stimulated release of ir-BNP from both cultured atrial and ventricular myocytes in a dose-dependent manner. Plasma BNP concentration is frequently increased in hyperthyroidism, and thyroid hormone may regulate BNP release from both atrial and ventricular myocytes.
本研究旨在探讨甲状腺激素在心脏脑钠肽（BNP）释放过程中的作用。我们检测了未经治疗的甲状腺功能亢进患者血浆中免疫反应性BNP（ir-BNP）的浓度。我们还检测了用甲状腺素（T4）诱导的甲状腺功能亢进实验大鼠以及用丙硫氧嘧啶（PTU）诱导的甲状腺功能减退大鼠的BNP值。在原代培养的新生大鼠心房和心室肌细胞中，研究了三碘甲状腺原氨酸（T3）和T4对BNP释放的体外影响。与正常对照受试者相比，甲状腺功能亢进患者的血浆BNP水平升高。与甲状腺功能正常的大鼠相比，甲状腺功能亢进大鼠的血浆BNP水平升高，而甲状腺功能减退大鼠的血浆BNP水平降低。甲状腺功能亢进患者和甲状腺功能亢进大鼠的血浆BNP水平与血清T4水平相关。甲状腺功能亢进患者血浆中ir-BNP的主要成分是人类BNP-32，而甲状腺功能亢进大鼠血浆中ir-BNP的主要成分是大鼠BNP-45。T4和T3以剂量依赖性方式刺激培养的心房和心室肌细胞释放ir-BNP。甲状腺功能亢进时血浆BNP浓度常升高，甲状腺激素可能调节心房和心室肌细胞释放BNP。
