Department of Animal ScienceIowa State University, Ames, IA, USA
Reproduction. 2018 Apr;155(4):R169-R181. doi: 10.1530/REP-17-0406. Epub 2018 Jan 23.
Endotoxemia can be caused by obesity, environmental chemical exposure, abiotic stressors and bacterial infection. Circumstances that deleteriously impact intestinal barrier integrity can induce endotoxemia, and controlled experiments have identified negative impacts of lipopolysaccharide (LPS; an endotoxin mimetic) on folliculogenesis, puberty onset, estrus behavior, ovulation, meiotic competence, luteal function and ovarian steroidogenesis. In addition, neonatal LPS exposures have transgenerational female reproductive impacts, raising concern about early life contacts to this endogenous reproductive toxicant. Aims of this review are to identify physiological stressors causing endotoxemia, to highlight potential mechanism(s) by which LPS compromises female reproduction and identify knowledge gaps regarding how acute and/or metabolic endotoxemia influence(s) female reproduction.
内毒素血症可由肥胖、环境化学暴露、非生物应激源和细菌感染引起。有害影响肠道屏障完整性的情况会导致内毒素血症，对照实验已经证实脂多糖（LPS；一种内毒素模拟物）对卵泡发生、青春期起始、发情行为、排卵、减数分裂能力、黄体功能和卵巢甾体生成有负面影响。此外，新生儿 LPS 暴露对女性生殖具有跨代影响，这引起了对内毒素这种内源性生殖毒物的早期生命接触的担忧。本综述的目的是确定导致内毒素血症的生理应激源，强调 LPS 损害女性生殖的潜在机制，并确定关于急性和/或代谢性内毒素血症如何影响女性生殖的知识空白。
