Universite de Lyon, F-69100 Villeurbanne, France.
Biochimie. 2011 Jan;93(1):39-45. doi: 10.1016/j.biochi.2010.04.016. Epub 2010 Apr 28.
Metabolic diseases such as obesity are characterized by a subclinical inflammatory state that contributes to the development of insulin resistance and atherosclerosis. Recent reports also indicate that (i) there are alterations of the intestinal microbiota in metabolic diseases and (ii) absorption of endogenous endotoxins (namely lipopolysaccharides, LPS) can occur, particularly during the digestion of lipids. The aim of the present review is to highlight recently gained knowledge regarding the links between high fat diets, lipid digestion, intestinal microbiota and metabolic endotoxemia & inflammation.
代谢性疾病（如肥胖症）的特征是亚临床炎症状态，这有助于发展胰岛素抵抗和动脉粥样硬化。最近的报告还表明：（i）代谢性疾病存在肠道微生物组的改变；（ii）内源性内毒素（即脂多糖，LPS）可以被吸收，尤其是在脂肪消化期间。本综述的目的是强调关于高脂肪饮食、脂肪消化、肠道微生物组与代谢性内毒素血症和炎症之间联系的最新知识。
