a VA San Diego Healthcare System , San Diego , California.
b Department of Psychiatry , University of California at San Diego , San Diego , California.
Behav Sleep Med. 2019 Jul-Aug;17(4):524-535. doi: 10.1080/15402002.2018.1425869. Epub 2018 Jan 24.
: Insomnia occurs in 66-90% of individuals with posttraumatic stress disorder (PTSD) and 36-72% of individuals with substance use disorder (SUD). Individuals with both PTSD and SUD are more likely to have insomnia than individuals with only one disorder. Insomnia is associated with poorer treatment outcomes for both PTSD and SUD, increased daytime symptomology for PTSD, and increased relapse for SUDs. As such, it is important to understand how sleep affects PTSD treatment among patients dually diagnosed with SUD and how sleep changes over time in a residential unit for SUDs. : Participants were 40 veterans with comorbid PTSD and SUD in a 28-day Substance Abuse Residential Rehabilitation Treatment Program (SARRTP) PTSD track. : Analyses used mixed models with Time (baseline, posttreatment, 3-month follow-up) to examine PTSD and insomnia severity over time. : Results of the longitudinal mixed model showed that PTSD symptoms improved over time but that insomnia symptoms did not. Although baseline insomnia did not affect follow-up PTSD symptoms, individuals with greater insomnia severity at the start of treatment had more severe baseline PTSD symptomatology. However, there was not an interaction of insomnia and PTSD severity over time such that baseline insomnia did not affect PTSD trajectories. : These findings are consistent with the PTSD outpatient treatment findings and further adds evidence that insomnia is unremitting without direct intervention. Given the relationship insomnia has with PTSD severity, SUD, and relapse, directly targeting insomnia may further help improve both PTSD and SUD treatment outcomes.
失眠症在创伤后应激障碍(PTSD)患者中发生率为 66%-90%,在物质使用障碍(SUD)患者中发生率为 36%-72%。同时患有 PTSD 和 SUD 的个体比仅患有一种障碍的个体更有可能患有失眠症。失眠症与 PTSD 和 SUD 的治疗效果较差、PTSD 的日间症状加重以及 SUD 的复发增加有关。因此,了解睡眠如何影响同时患有 SUD 和 PTSD 的患者的 PTSD 治疗以及在 SUD 住院治疗单元中睡眠随时间的变化非常重要。
参与者为 40 名患有共病 PTSD 和 SUD 的退伍军人,他们参加了为期 28 天的物质滥用住院康复治疗计划(SARRTP)PTSD 跟踪治疗。
分析采用混合模型,时间(基线、治疗后、3 个月随访)用于随时间检查 PTSD 和失眠严重程度。
纵向混合模型的结果表明,PTSD 症状随时间改善,但失眠症状没有改善。虽然基线失眠症并不影响随访时的 PTSD 症状,但在治疗开始时失眠症严重程度较高的个体在基线时的 PTSD 症状更为严重。然而,失眠症和 PTSD 严重程度之间没有随时间变化的相互作用,即基线失眠症并不影响 PTSD 轨迹。
这些发现与 PTSD 门诊治疗的发现一致,并进一步证明失眠症在没有直接干预的情况下持续存在。鉴于失眠症与 PTSD 严重程度、SUD 和复发之间的关系,直接针对失眠症可能会进一步有助于改善 PTSD 和 SUD 的治疗效果。