蛙皮素对大鼠苯丙胺诱导的多动行为长期拮抗作用机制的研究

Study on the mechanism of the long-lasting antagonistic effect of caerulein on amphetamine-induced hyperactivity in rats.

作者信息

Matsubara K, Matsushita A

出版信息

Gen Pharmacol. 1986;17(1):13-7. doi: 10.1016/0306-3623(86)90004-2.

Abstract

The long-lasting antagonistic effect of caerulein (CLN) on amphetamine (AMP) hyperactivity was abolished in rats following partial 6-OHDA lesions of the nucleus accumbens (NA) or dopamine (DA) A10 area. CLN showed the long-term antagonistic effect on AMP hyperactivity in rats following complete 6-OHDA lesions of the DA A9 area. Neonatal monosodium L-glutamate-treated rats did not show the CLN effect. These results suggest that opiate receptors presynaptically located on DA neurons in the NA and some modulatory changes in the beta-endorphin system in the arcuate nucleus may play an important role in producing the CLN effect.

摘要

在伏隔核（NA）或多巴胺（DA）A10区部分6-羟基多巴胺（6-OHDA）损伤后的大鼠中，蛙皮素（CLN）对苯丙胺（AMP）所致活动亢进的长期拮抗作用被消除。在DA A9区完全6-OHDA损伤后的大鼠中，CLN对AMP所致活动亢进表现出长期拮抗作用。新生期经L-谷氨酸单钠处理的大鼠未表现出CLN效应。这些结果表明，位于NA区DA神经元上的突触前阿片受体以及弓状核β-内啡肽系统的一些调节性变化可能在产生CLN效应中起重要作用。