Matsubara K, Matsushita A
Jpn J Pharmacol. 1985 Nov;39(3):317-21. doi: 10.1254/jjp.39.317.
The present experiments were performed in order to ascertain whether the long-term antagonistic effect of caerulein on amphetamine-induced hyperactivity is produced in the central nervous system. In the vagotomized rats, animals treated with a combination of caerulein and haloperidol and exposed to amphetamine on the 1st day became less sensitive to amphetamine for 24 hr to 1 week when their ambulatory activities were measured in an open field apparatus. The same results were also observed in the experiments where caerulein was applied directly into the lateral ventricle. However, the animals given caerulein in the nucleus accumbens showed no reduced susceptibility to amphetamine. Thus, the present results suggest that caerulein may indirectly modulate some dopaminergic activity in the central nervous system. One possible mechanism involved in the antagonistic effect of caerulein on amphetamine-induced hyperactivity is changes in activities of endocrine systems.
进行本实验是为了确定蛙皮素对苯丙胺诱导的多动的长期拮抗作用是否在中枢神经系统中产生。在迷走神经切断的大鼠中，当在旷场装置中测量其活动能力时，第1天用蛙皮素和氟哌啶醇联合处理并接触苯丙胺的动物在24小时至1周内对苯丙胺的敏感性降低。在将蛙皮素直接注入侧脑室的实验中也观察到了相同的结果。然而，在伏隔核中给予蛙皮素的动物对苯丙胺的敏感性没有降低。因此，目前的结果表明，蛙皮素可能间接调节中枢神经系统中的一些多巴胺能活动。蛙皮素对苯丙胺诱导的多动的拮抗作用所涉及的一种可能机制是内分泌系统活动的变化。
