Department of Dermatology and Allergology, Ludwig-Maximilians Universität, Munich, Germany.
Department of Dermatology and Allergology, Ludwig-Maximilians Universität, Munich, Germany.
J Allergy Clin Immunol. 2018 Mar;141(3):858-866. doi: 10.1016/j.jaci.2017.10.045. Epub 2018 Feb 1.
IL-31 is a novel cytokine expressed in many human tissues and involved mainly in T2-weighted inflammation. IL-31 signals through a receptor complex consisting of IL-31 receptor α and oncostatin M receptor β. The available data show that IL-31 is strongly linked with chronic pruritic skin disorders, such as atopic eczema, and represents a novel target for directed drug therapy. Regulation of immune responses and cellular differentiation and proliferation are recently elucidated effects of IL-31, suggesting a more complex and diverse area of effect for this novel cytokine. This review summarizes the current knowledge on IL-31 and its receptors and the involvement of IL-31 in diseases both in human subjects and mouse models.
白细胞介素 31 是一种新型细胞因子，在许多人体组织中表达，主要参与 T2 加权炎症。白细胞介素 31 通过由白细胞介素 31 受体 α 和肿瘤坏死因子受体 β 组成的受体复合物传递信号。现有数据表明，白细胞介素 31 与慢性瘙痒性皮肤疾病密切相关，如特应性皮炎，是靶向药物治疗的新靶点。白细胞介素 31 对免疫反应、细胞分化和增殖的调节作用是其最近阐明的作用，这表明该新型细胞因子具有更复杂和多样化的作用区域。这篇综述总结了目前关于白细胞介素 31 及其受体的知识，以及白细胞介素 31 在人类和小鼠模型中疾病中的作用。
