Department of Biology, Animal Physiology and Neurobiology Section, KU Leuven, Naamsestraat 59, box 2465, 3000 Leuven, Belgium.
Department of Biology, Animal Physiology and Neurobiology Section, KU Leuven, Naamsestraat 59, box 2465, 3000 Leuven, Belgium; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Herestraat 49, box 921, 3000 Leuven, Belgium.
J Ethnopharmacol. 2018 Apr 24;216:229-232. doi: 10.1016/j.jep.2018.01.024. Epub 2018 Jan 31.
Tetradenia (T.) riparia (Hochst.) Codd (Lamiaceae), formerly known as Iboza riparia (Hochst.) N.E.Br., is one of the most frequently used medicinal plants in traditional Rwandese medicine. It was used as a remedy against a wide range of diseases including malaria, angina, yaws, dental abscesses, headache, worm infections and several kinds of fevers and aches.
This study aims to identify the compounds active against helminths from Tetradenia riparia.
A bioassay-guided isolation of anthelmintic compounds from the leaves of Tetradenia riparia was performed using a Caenorhabditis elegans (C. elegans) testing model.
The bioassay-guided isolation led to one active compound, i.e. 8(14),15-sandaracopimaradiene-7α,18-diol. Its IC value was 5.4 ± 0.9 µg/mL (17.8 ± 2.9 µM).
We identified the bioactive compound from Tetradenia riparia responsible for its anthelmintic activity: 8(14),15-sandaracopimaradiene-7α,18-diol. Although the compound and several of its bioactivities have been described before, this is the first report of its anthelmintic effect.
Tetradenia (T.) riparia (Hochst.) Codd（唇形科），以前称为 Iboza riparia (Hochst.) N.E.Br.，是卢旺达传统医学中使用最频繁的药用植物之一。它被用作治疗各种疾病的药物，包括疟疾、心绞痛、雅司病、齿槽脓肿、头痛、蠕虫感染和多种发热和疼痛。
本研究旨在从 Tetradenia riparia 中鉴定出对抗寄生虫的化合物。
使用秀丽隐杆线虫（C. elegans）测试模型，对 Tetradenia riparia 的叶子中的驱虫化合物进行基于生物测定的分离。
基于生物测定的分离导致一种活性化合物，即 8(14),15-松香二烯-7α,18-二醇。其 IC 值为 5.4 ± 0.9μg/mL（17.8 ± 2.9μM）。
我们从 Tetradenia riparia 中鉴定出负责其驱虫活性的生物活性化合物：8(14),15-松香二烯-7α,18-二醇。尽管该化合物及其几种生物活性以前已经描述过，但这是其驱虫作用的首次报道。
