College of Chemistry, Jilin University, Changchun 130021, People's Republic of China.
College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China.
Colloids Surf B Biointerfaces. 2018 Mar 1;163:402-411. doi: 10.1016/j.colsurfb.2018.01.013. Epub 2018 Jan 11.
A novel N-halamine terpolymer, i.e., P(ADMH-MMA-HEMA)-Cl, with high antibacterial efficacies were fabricated via a free-radical copolymerization of 3-allyl-5,5-dimethylhydantoin(ADMH), methyl methacrylate(MMA), and hydroxyethyl methacrylate (HEMA), followed by a chlorination treatment using sodium hypochlorite as chlorinating agent. A controllable synthesis of P(ADMH-MMA-HEMA)-Cl was achieved by tuning chlorination conditions, such as chlorination temperature, reactant concentration, chlorination time, etc. A series of antibacterial assays were conducted, and the as-prepared products P(ADMH-MMA-HEMA)-Cl showed good killing capabilities against both Gram-positive and Gram negative bacteria. Remarkably, compared to N-halamine biopolymer counterparts, e.g., P(ADMH-HEMA)-Cl and P(ADMH-MMA)-Cl, and the as-prepared N-halamine terpolymer P(ADMH-MMA-HEMA)-Cl presented the enhancement in antibacterial efficiency toward pathogens. It is believed that this approach offers great potential to be utilized in various fields where antibacterial properties are highly required.
通过自由基共聚 3-烯丙基-5,5-二甲基海因（ADMH）、甲基丙烯酸甲酯（MMA）和甲基丙烯酸羟乙酯（HEMA），然后用次氯酸钠作为氯化剂进行氯化处理，制备了具有高效抗菌性能的新型 N-卤胺三元共聚物，即 P(ADMH-MMA-HEMA)-Cl。通过调节氯化条件，如氯化温度、反应物浓度、氯化时间等，可以实现 P(ADMH-MMA-HEMA)-Cl 的可控合成。进行了一系列抗菌试验，所制备的 P(ADMH-MMA-HEMA)-Cl 对革兰氏阳性菌和革兰氏阴性菌均表现出良好的杀灭能力。值得注意的是，与 N-卤胺生物聚合物对照物，例如 P(ADMH-HEMA)-Cl 和 P(ADMH-MMA)-Cl 相比，所制备的 N-卤胺三元共聚物 P(ADMH-MMA-HEMA)-Cl 对病原体的抗菌效率得到了提高。相信这种方法在需要抗菌性能的各个领域具有很大的应用潜力。
