Li Lin, Ma Wei, Cheng Xiaoli, Ren Xuehong, Xie Zhiwei, Liang Jie
Key Laboratory of Eco-Textiles of Ministry of Education, Jiangsu Engineering Technology Research Center for Functional Textiles, College of Textiles and Clothing, Jiangnan University, Wuxi, Jiangsu 214122, China.
Key Laboratory of Eco-Textiles of Ministry of Education, Jiangsu Engineering Technology Research Center for Functional Textiles, College of Textiles and Clothing, Jiangnan University, Wuxi, Jiangsu 214122, China.
Colloids Surf B Biointerfaces. 2016 Dec 1;148:511-517. doi: 10.1016/j.colsurfb.2016.09.030. Epub 2016 Sep 22.
As one of the most powerful biocides, N-halamine based antimicrobial materials have attracted much interest due to their non-toxicity, rechargeability, and rapid inactivation against a broad range of microorganisms. In this study, novel titanium dioxide-ADMH core-shell nanoparticles [TiO@poly (ADMH-co-MMA) NPs] were prepared via miniemulsion polymerization using 3-allyl-5,5-dimethylhydantoin (ADMH) and methyl methacrylate (MMA) with nano-TiO. The produced nanoparticles were characterized by FT-IR, TEM, TGA, and XPS. The UV stability of N-halamine nanoparticles has been improved with the addition of titanium dioxide. After chlorination treatment by sodium hypochlorite, biocidal efficacies of the chlorinated nanoparticles against S. aureus (ATCC 6538) and E. coli O157:H7 (ATCC 43895) were determined. The nanoparticles showed excellent antimicrobial properties against bacteria within brief contact time. In addition, in vitro cell cytocompatibility tests showed that the antibacterial nanoparticles had good biocompatibility.
作为最强大的杀生剂之一，基于N-卤胺的抗菌材料因其无毒、可再充电以及对多种微生物的快速灭活能力而备受关注。在本研究中，通过微乳液聚合，使用3-烯丙基-5,5-二甲基乙内酰脲（ADMH）、甲基丙烯酸甲酯（MMA）与纳米TiO₂制备了新型二氧化钛-ADMH核壳纳米颗粒[TiO₂@聚（ADMH-co-MMA）纳米颗粒]。通过傅里叶变换红外光谱（FT-IR）、透射电子显微镜（TEM）、热重分析（TGA）和X射线光电子能谱（XPS）对所制备的纳米颗粒进行了表征。通过添加二氧化钛提高了N-卤胺纳米颗粒的紫外线稳定性。经次氯酸钠氯化处理后，测定了氯化纳米颗粒对金黄色葡萄球菌（ATCC 6538）和大肠杆菌O157:H7（ATCC 43895）的杀菌效果。这些纳米颗粒在短接触时间内对细菌表现出优异的抗菌性能。此外，体外细胞相容性测试表明，抗菌纳米颗粒具有良好的生物相容性。
