Stary A
Hautarzt. 1986 Jan;37(1):28-30.
Four weeks after the introduction of a therapeutic regimen with 80 mg 13-cis-retinoic acid/day, a 16-year-old male patient developed oozing hypergranulation with vulnerable masses within acne lesions. These local symptoms were accompanied by fever, fatigue, weight loss, polyarthralgia and myalgia, similar to acne fulminans. In spite of these unusual reactions treatment was continued. Local steroid ointments were additionally applied. Within a short period of time regression of granulations and normalization of the general health condition was observed. After 4 months, therapy was discontinued. The patient's acne had totally healed and did not relapse within an observation period of 2 years.
在开始每天服用80毫克13 - 顺式维甲酸的治疗方案四周后，一名16岁男性患者在痤疮皮损内出现渗液性肉芽组织增生，并伴有易破溃的肿块。这些局部症状伴有发热、疲劳、体重减轻、多关节痛和肌痛，类似于暴发性痤疮。尽管出现了这些异常反应，治疗仍继续进行。此外还局部应用了类固醇软膏。短时间内观察到肉芽组织消退，全身健康状况恢复正常。4个月后，停止治疗。患者的痤疮已完全治愈，在2年的观察期内未复发。
