Plewig G, Wagner A, Braun-Falco O
MMW Munch Med Wochenschr. 1980 Sep 19;122(38):1287-93.
A new, very effective method of treating severe forms of acne (papuplopustular, conglobate, fulminating and tetrad) is the oral administration of 13-cis-retinoic acid. The results described by Peck et al. (1979) in 14 patients are demonstrated in detail in 18 patients. In the initial therapy 1 to 2 mg/kg body weight were administered daily for 12 weeks without any other local or systemic treatment. In the second phase of the study half the patients continued treatment with 0.5 mg/kg body weight 13-cis-retinoic acid, the other half remaining without any further therapy. All inflammatory lesions healed after 12-16 weeks, sebum production was largely reduced. 13-cis-retinoic acid represents a remarkable turn in the treatment of most severe acne.
一种治疗重度痤疮（丘疹脓疱型、聚合性、暴发性和四型痤疮）的全新且非常有效的方法是口服13 - 顺式维甲酸。佩克等人（1979年）在14名患者身上所描述的结果在18名患者身上得到了详细验证。在初始治疗阶段，每天给予1至2毫克/千克体重的剂量，持续12周，不进行任何其他局部或全身治疗。在研究的第二阶段，一半患者继续使用0.5毫克/千克体重的13 - 顺式维甲酸进行治疗，另一半则不再接受任何进一步治疗。所有炎症性皮损在12 - 16周后愈合，皮脂分泌大幅减少。13 - 顺式维甲酸代表了重度痤疮治疗方面的重大转变。
