The in-vitro comparative activity of quinolones against bacteria from urinary tract infections in general practice.

In a study of lower urinary tract infection in general practice over twelve hundred strains have been isolated. Eight hundred and sixty-six consecutive strains were tested against four quinolone compounds. Sixty-nine per cent of the isolates were Escherichia coli and 15% coagulase-negative staphylococci (mostly Staphylococcus saprophyticus). The diffusion method, according to I.C.S. recommendation, was used and standardized for extrapolation of MIC results. Ciprofloxacin followed by norfloxacin and pefloxacin, was the most active quinolone compound (MIC 0 X 015-2 mg/l) against all strains, including multiresistant ones.