Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, 410078, Changsha, China.
Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, 410078, Changsha, China.
Biomed Pharmacother. 2018 Mar;99:363-368. doi: 10.1016/j.biopha.2018.01.037.
MIR31HG, as the host gene of miR-31, has been suggested to involve in various cancer developments. However, little is known about the clinical significance and biological function of MIR31HG in lung adenocarcinoma. In our study, we found MIR31HG was highly expressed in lung adenocarcinoma tissues and cell lines, and associated with clinical staging, N classification, M classification and differentiated degree. Survival analysis showed MIR31HG high-expression was an independent unfavorable prognostic factor for lung adenocarcinoma patients. Loss-of-function studies suggested down-regulation of MIR31HG inhibited lung adenocarcinoma cells proliferation and blocked cell-cycle, but has no effect on cell apoptosis. There was no correlation between MIR31HG and miR-31 expression in lung adenocarcinoma tissues, down-regulation of MIR31HG had no effect on the expression of miR-31 in lung adenocarcinoma cells. In conclusion, MIR31HG high-expression is an independent unfavorable prognostic factor for lung adenocarcinoma patients, and serves an oncogenic role to modulate lung adenocarcinoma cells proliferation and cell-cycle.
MIR31HG 作为 miR-31 的宿主基因，被认为参与多种癌症的发展。然而，关于 MIR31HG 在肺腺癌中的临床意义和生物学功能知之甚少。在我们的研究中，我们发现 MIR31HG 在肺腺癌组织和细胞系中高表达，并与临床分期、N 分类、M 分类和分化程度相关。生存分析表明，MIR31HG 高表达是肺腺癌患者的独立不良预后因素。功能丧失研究表明，下调 MIR31HG 抑制肺腺癌细胞增殖并阻断细胞周期，但对细胞凋亡没有影响。MIR31HG 与肺腺癌组织中的 miR-31 表达之间没有相关性，下调 MIR31HG 对肺腺癌细胞中 miR-31 的表达没有影响。总之，MIR31HG 高表达是肺腺癌患者的独立不良预后因素，作为癌基因调节肺腺癌细胞增殖和细胞周期。
