Zhang Ling, He Jian-Bo
Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, School of Life Sciences, Southwest University, Chongqing 400715, China.
Yi Chuan. 2018 Jan 20;40(1):22-32. doi: 10.16288/j.yczz.17-163.
GATA binding protein 6 (GATA6) is a member of the GATA family of zinc-finger transcriptional regulators, whose names come from the conservative base sequence (G/A)GATA(A/T). The GATA families play key roles in cell fate determination, proliferation, migration, and organogenesis of endoderm- and mesoderm-derived organs in vertebrates. As a lineage-specific factor, a chromatin remodeling factor, a pluripotent factor and a pioneer factor, GATA6 is involved in various stages of liver development, including endoderm liver-lineage determination, liver specification, hepatic bud outgrowth and hepatoblast differentiation. In this review, we summarize recent progress in the roles and regulatory mechanisms of GATA6 in liver development.
GATA结合蛋白6（GATA6）是锌指转录调节因子GATA家族的成员，该家族名称源于保守碱基序列（G/A）GATA（A/T）。GATA家族在脊椎动物内胚层和中胚层来源器官的细胞命运决定、增殖、迁移及器官发生过程中发挥关键作用。作为一种谱系特异性因子、染色质重塑因子、多能因子和先锋因子，GATA6参与肝脏发育的各个阶段，包括内胚层肝谱系决定、肝脏特化、肝芽长出及肝母细胞分化。在本综述中，我们总结了GATA6在肝脏发育中的作用及调控机制的最新进展。
